TY - GEN
T1 - Imaging-based integrative models of the heart
T2 - Closing the loop between experiment and simulation
AU - Winslow, Raimond L.
AU - Helm, Patrick
AU - Baumgartner, William
AU - Peddi, Srinivas
AU - Ratnanather, Tilak
AU - McVeigh, Elliot
AU - Miller, Michael I.
AU - Hunter,
AU - McCulloch,
PY - 2002
Y1 - 2002
N2 - We describe methodologies for: (a) mapping ventricular activation using high-density epicardial electrode arrays; (b) measuring and modelling ventricular geometry and fibre orientation at high spatial resolution using diffusion tensor magnetic resonance imaging (DTMRI); and (c) simulating electrical conduction; using comprehensive data sets collected from individual canine hearts. We demonstrate that computational models based on these experimental data sets yield reasonably accurate reproduction of measured epicardial activation patterns. We believe this ability to electrically map and model individual hearts will lead to enhanced understanding of the relationship between anatomical structure, and electrical conduction in the cardiac ventricles.
AB - We describe methodologies for: (a) mapping ventricular activation using high-density epicardial electrode arrays; (b) measuring and modelling ventricular geometry and fibre orientation at high spatial resolution using diffusion tensor magnetic resonance imaging (DTMRI); and (c) simulating electrical conduction; using comprehensive data sets collected from individual canine hearts. We demonstrate that computational models based on these experimental data sets yield reasonably accurate reproduction of measured epicardial activation patterns. We believe this ability to electrically map and model individual hearts will lead to enhanced understanding of the relationship between anatomical structure, and electrical conduction in the cardiac ventricles.
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M3 - Conference contribution
C2 - 12539953
AN - SCOPUS:0038819907
T3 - Novartis Foundation Symposium
SP - 129
EP - 143
BT - Novartis Foundation Symposium
ER -