IMAGE reconstruction for small animal spect with two opposing half cones

Yibin Zheng, Heng Li, Jiong Wang, Alexander V. Stolin, Joe Pole, Mark B. Williams

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Pinhole imaging is a promising approach for high spatial resolution single gamma emission imaging in situations when the required field of view (FOV) is small, as is the case for small animal imaging. However, all pinhole collimators exhibit steep decrease in sensitivity with increasing angle of incidence from the pinhole axis. This in turn degrades the reconstruction images, and requires higher dose of radiotracer. We developed a novel pinhole SPECT system for small animal imaging which uses two opposing and offset small cone-angle square pinholes, each looking at half of the FOV. This design allows the pinholes to be placed closer to the object and greatly increases detection efficiency and spatial resolution, while not requiring larger size detectors. Iterative image reconstruction algorithms for this system have been developed. Preliminary experimental data have demonstrated marked improvement in contrast and spatial resolution.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE-IS and T Electronic Imaging - Computational Imaging V
DOIs
StatePublished - Aug 31 2007
Externally publishedYes
EventComputational Imaging V - San Jose, CA, United States
Duration: Jan 29 2007Jan 31 2007

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume6498
ISSN (Print)0277-786X

Conference

ConferenceComputational Imaging V
CountryUnited States
CitySan Jose, CA
Period1/29/071/31/07

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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  • Cite this

    Zheng, Y., Li, H., Wang, J., Stolin, A. V., Pole, J., & Williams, M. B. (2007). IMAGE reconstruction for small animal spect with two opposing half cones. In Proceedings of SPIE-IS and T Electronic Imaging - Computational Imaging V [649804] (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 6498). https://doi.org/10.1117/12.713940