Image-guided core breast biopsy of ductal carcinoma in situ presenting as a non-calcified abnormality

Pamela J. DiPiro, Jack E. Meyer, Christine M. Denison, Thomas H. Frenna, Susan C. Harvey, Darrell N. Smith

Research output: Contribution to journalArticlepeer-review


Objective: Ductal carcinoma in situ (DCIS) typically presents as calcifications which are detected mammographically. Our aim was to evaluate the less common presentations of ductal carcinoma in situ diagnosed by image- guided core biopsy and correlate with histopathologic diagnoses. Methods and Material: Imaging and histopathologic findings were retrospectively reviewed in 11 patients with ductal carcinoma in situ diagnosed at core biopsy that presented as noncalcified radiographic abnormalities. Results: Mammography showed non-calcified, circumscribed nodules, ill-defined nodules and architectural distortion. In two patients, no mammographic abnormality was detected. Sonography showed circumscribed, round or oval, solid masses; irregular, heterogeneous masses; and a tubular structure. Histopathologic diagnoses included multiple architectural subtypes and ranged from low to high nuclear grade. Conclusion: Although image-guided core biopsy diagnosis of ductal carcinoma is typically made when sampling calcifications, DCIS can be diagnosed following biopsy of non-calcified masses or distortion. There is no correlation between histopathologic subtype and radiologic appearance.

Original languageEnglish (US)
Pages (from-to)231-236
Number of pages6
JournalEuropean Journal of Radiology
Issue number3
StatePublished - Jun 1 1999


  • Core breast biopsy
  • Ductal carcinoma in situ (DCIS)

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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