Image-based reconstruction of 3D myocardial infarct geometry for patient specific applications

Eranga Ukwatta, Martin Rajchl, James White, Farhad Pashakhanloo, Daniel Herzka, Elliot McVeigh, Albert C. Lardo, Natalia Trayanova, Fijoy Vadakkumpadan

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Accurate reconstruction of the three-dimensional (3D) geometry of a myocardial infarct from two-dimensional (2D) multi-slice image sequences has important applications in the clinical evaluation and treatment of patients with ischemic cardiomyopathy. However, this reconstruction is challenging because the resolution of common clinical scans used to acquire infarct structure, such as short-axis, late-gadolinium enhanced cardiac magnetic resonance (LGE-CMR) images, is low, especially in the out-of-plane direction. In this study, we propose a novel technique to reconstruct the 3D infarct geometry from low resolution clinical images. Our methodology is based on a function called logarithm of odds (LogOdds), which allows the broader class of linear combinations in the LogOdds vector space as opposed to being limited to only a convex combination in the binary label space. To assess the efficacy of the method, we used high-resolution LGE-CMR images of 36 human hearts in vivo, and 3 canine hearts ex vivo. The infarct was manually segmented in each slice of the acquired images, and the manually segmented data were downsampled to clinical resolution. The developed method was then applied to the downsampled image slices, and the resulting reconstructions were compared with the manually segmented data. Several existing reconstruction techniques were also implemented, and compared with the proposed method. The results show that the LogOdds method significantly outperforms all the other tested methods in terms of region overlap.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2015: Image Processing
ISBN (Print)9781628415032
Publication statusPublished - 2015
EventMedical Imaging 2015: Image Processing - Orlando, United States
Duration: Feb 24 2015Feb 26 2015


OtherMedical Imaging 2015: Image Processing
CountryUnited States



  • Image-based Reconstruction
  • Interpolation
  • Logarithm of Odds
  • Myocardial Infarct

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Ukwatta, E., Rajchl, M., White, J., Pashakhanloo, F., Herzka, D., McVeigh, E., ... Vadakkumpadan, F. (2015). Image-based reconstruction of 3D myocardial infarct geometry for patient specific applications. In Medical Imaging 2015: Image Processing (Vol. 9413). [94132W] SPIE.