TY - GEN
T1 - Image-based estimation of ventricular fiber orientations for patient-specific simulations
AU - Vadakkumpadan, Fijoy
AU - Arevalo, Hermenegild
AU - Ceritoglu, Can
AU - Miller, Michael
AU - Trayanova, Natalia
PY - 2011
Y1 - 2011
N2 - Patient-specific simulation of heart (dys)function aimed at personalizing cardiac therapy are hampered by the absence of in vivo imaging technology for clinically acquiring myocardial fiber orientations. In this research, we develop a methodology to predict ventricular fiber orientations of a patient heart, given the geometry of the heart and an atlas. We test the methodology by comparing the estimated fiber orientations with measured ones, and by quantifying the effect of the estimation error on outcomes of electrophysiological simulations, in normal and failing canine hearts. The new insights obtained from the project will pave the way for the development of patient-specific models of the heart that can aid physicians in personalized diagnosis and decisions regarding electrophysiological interventions.
AB - Patient-specific simulation of heart (dys)function aimed at personalizing cardiac therapy are hampered by the absence of in vivo imaging technology for clinically acquiring myocardial fiber orientations. In this research, we develop a methodology to predict ventricular fiber orientations of a patient heart, given the geometry of the heart and an atlas. We test the methodology by comparing the estimated fiber orientations with measured ones, and by quantifying the effect of the estimation error on outcomes of electrophysiological simulations, in normal and failing canine hearts. The new insights obtained from the project will pave the way for the development of patient-specific models of the heart that can aid physicians in personalized diagnosis and decisions regarding electrophysiological interventions.
UR - http://www.scopus.com/inward/record.url?scp=84862255073&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84862255073&partnerID=8YFLogxK
U2 - 10.1109/IEMBS.2011.6090481
DO - 10.1109/IEMBS.2011.6090481
M3 - Conference contribution
C2 - 22254646
AN - SCOPUS:84862255073
SN - 9781424441211
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 1672
EP - 1675
BT - 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
T2 - 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
Y2 - 30 August 2011 through 3 September 2011
ER -