IL28B polymorphism does not determine outcomes of hepatitis B virus or HIV infection

Maureen P. Martin, Ying Qi, James J. Goedert, Shehnaz K. Hussain, Gregory D Kirk, W. Keith Hoots, Susan Buchbinder, Mary Carrington, Chloe L Thio

Research output: Contribution to journalArticle

Abstract

An IL28B haplotype strongly determines the outcome of natural and interferon-α treated hepatitis C virus (HCV) infection. To assess whether the polymorphism marking the haplotype (rs12979860) also affects other interferon-α responsive chronic viral illnesses, namely hepatitis B virus (HBV) and human immunodeficiency virus (HIV) type 1 infections, we genotyped 226 individuals with HBV persistence, 384 with HBV recovery, and 2548 with or at high risk for HIV infection. The C/C genotype of rs12979860 was not associated with HBV recovery (odds ratio, 0.99), resistance to HIV infection (odds ratio, 0.97), or HIV disease progression (P > .05). This IL28B single-nucleotide polymorphism affects the immune response to HCV but not to HBV or HIV.

Original languageEnglish (US)
Pages (from-to)1749-1753
Number of pages5
JournalJournal of Infectious Diseases
Volume202
Issue number11
DOIs
StatePublished - Dec 1 2010

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Virus Diseases
Hepatitis B virus
HIV
Hepacivirus
Haplotypes
Interferons
Odds Ratio
Single Nucleotide Polymorphism
Disease Progression
HIV-1
Chronic Disease
Genotype

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy

Cite this

IL28B polymorphism does not determine outcomes of hepatitis B virus or HIV infection. / Martin, Maureen P.; Qi, Ying; Goedert, James J.; Hussain, Shehnaz K.; Kirk, Gregory D; Hoots, W. Keith; Buchbinder, Susan; Carrington, Mary; Thio, Chloe L.

In: Journal of Infectious Diseases, Vol. 202, No. 11, 01.12.2010, p. 1749-1753.

Research output: Contribution to journalArticle

Martin, MP, Qi, Y, Goedert, JJ, Hussain, SK, Kirk, GD, Hoots, WK, Buchbinder, S, Carrington, M & Thio, CL 2010, 'IL28B polymorphism does not determine outcomes of hepatitis B virus or HIV infection', Journal of Infectious Diseases, vol. 202, no. 11, pp. 1749-1753. https://doi.org/10.1086/657146
Martin, Maureen P. ; Qi, Ying ; Goedert, James J. ; Hussain, Shehnaz K. ; Kirk, Gregory D ; Hoots, W. Keith ; Buchbinder, Susan ; Carrington, Mary ; Thio, Chloe L. / IL28B polymorphism does not determine outcomes of hepatitis B virus or HIV infection. In: Journal of Infectious Diseases. 2010 ; Vol. 202, No. 11. pp. 1749-1753.
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