IL18 and IL18R1 polymorphisms, lung CT and fibrosis: A longitudinal study in coal mines

R. Nadif, M. Mintz, J. Marzec, A. Jedlicka, F. Kauffmann, S. R. Kleeberger

Research output: Contribution to journalArticlepeer-review

Abstract

It has been suggested that interleukin (IL)-18 plays a role in the development of inflammatory and fibrosing lung diseases. Associations of polymorphisms in the genes coding for IL-18 (IL18/ G-656T, C-607A, G-137C, T113G, C127T) and its receptor (IL18R1/C-69T) with coal workers' pneumoconiosis (CWP) were studied in 200 miners who were examined in 1990, 1994 and 1999. Coal-dust exposure was assessed according to job history and ambient measures. The main health outcome was lung computed tomography (CT) score in 1990. Internal coherence was assessed by studying CT score in 1994, 4-yr change in CT score and CWP incidence and prevalence. CT score in 1990 was a good predictor of radiographic grade in 1999 and, therefore, an appropriate subclinical quantitative trait. The IL18 -137C allele was associated with lower CT score in 1990 and 1994 (1.24 versus 1.69 and 1.57 versus 2.46, respectively), slower progression of CT score between 1990 and 1994 and lower pneumoconiosis prevalence in 1999 relative to the G allele (0.33 versus 0.77 and 8.2 versus 19.6%, respectively). Smoking- or dust-adjustment, and stratification on IL18R1 genotype and adjustment for haplotype effects did not change the conclusions. In conclusion, the results of the present study suggest a role for IL18 in reducing the development of this fibrosing lung disease.

Original languageEnglish (US)
Pages (from-to)1100-1105
Number of pages6
JournalEuropean Respiratory Journal
Volume28
Issue number6
DOIs
StatePublished - Dec 2006

Keywords

  • Computed tomography
  • Epidemiology
  • Genetics
  • IL18
  • IL18R1

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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