IL-7 in human health and disease

Wangko Lundström, Natasha M. Fewkes, Crystal L. Mackall

Research output: Contribution to journalArticle

Abstract

IL-7 plays many essential roles in human health and disease. Congenital deficiencies in IL-7 signaling result in profound immunodeficiency, polymorphisms in IL7Rα modulate susceptibility to autoimmune disease, and acquired somatic activating mutations in IL7Rα contribute to neoplastic transformation in B cell and T cell leukemia. In response to lymphopenia, IL-7 accumulates to supranormal levels, which alters T cell homeostasis by augmenting T cell reactivity toward self and cognate antigens. This physiologic response is now routinely exploited to improve the efficacy of adoptive cell therapies for cancer. Clinical trials of recombinant IL-7 have demonstrated safety and potent immunorestorative effects, and current studies are investigating whether rhIL-7 therapy can improve outcomes in chronic viral infection and in the context of cancer immunotherapies. Building upon the large fund of knowledge regarding the basic biology of IL-7, this review will discuss the many and varied roles of IL-7 in human health and disease.

Original languageEnglish (US)
Pages (from-to)218-224
Number of pages7
JournalSeminars in Immunology
Volume24
Issue number3
DOIs
StatePublished - Jun 2012
Externally publishedYes

Fingerprint

Interleukin-7
Health
T-Lymphocytes
T-Cell Leukemia
Lymphopenia
Autoantigens
Financial Management
Virus Diseases
Cell- and Tissue-Based Therapy
Immunotherapy
Autoimmune Diseases
Neoplasms
Homeostasis
B-Lymphocytes
Clinical Trials
Safety
Mutation

Keywords

  • Autoimmunity
  • Cancer
  • Interleukin-7
  • Interleukin-7 receptor

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Lundström, W., Fewkes, N. M., & Mackall, C. L. (2012). IL-7 in human health and disease. Seminars in Immunology, 24(3), 218-224. https://doi.org/10.1016/j.smim.2012.02.005

IL-7 in human health and disease. / Lundström, Wangko; Fewkes, Natasha M.; Mackall, Crystal L.

In: Seminars in Immunology, Vol. 24, No. 3, 06.2012, p. 218-224.

Research output: Contribution to journalArticle

Lundström, W, Fewkes, NM & Mackall, CL 2012, 'IL-7 in human health and disease', Seminars in Immunology, vol. 24, no. 3, pp. 218-224. https://doi.org/10.1016/j.smim.2012.02.005
Lundström W, Fewkes NM, Mackall CL. IL-7 in human health and disease. Seminars in Immunology. 2012 Jun;24(3):218-224. https://doi.org/10.1016/j.smim.2012.02.005
Lundström, Wangko ; Fewkes, Natasha M. ; Mackall, Crystal L. / IL-7 in human health and disease. In: Seminars in Immunology. 2012 ; Vol. 24, No. 3. pp. 218-224.
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