TY - JOUR
T1 - IL-6 gene variation is not associated with increased serum levels of IL-6, muscle, weakness, or frailty in older women
AU - Walston, J.
AU - Arking, D. E.
AU - Fallin, D.
AU - Li, T.
AU - Beamer, B.
AU - Xue, Q.
AU - Ferrucci, L.
AU - Fried, L. P.
AU - Chakravarti, A.
N1 - Funding Information:
This research was supported by the National Institute on Aging, Claude D. Pepper Older Americans Independence Centers, Grant P30 AG021334, and NIH-NIA Grants R37 AG19905 and R01 AG11703, and by the GCRC NIH-NCRR Grant M01-RR000052 at the Johns Hopkins School of Medicine, and the Johns Hopkins Bayview Medical Center GCRC, Grant M01-RR-02719.
PY - 2005/4
Y1 - 2005/4
N2 - Elevated levels of the inflammatory cytokine IL-6 are associated with the development of disability, frailty, and mortality in older adults. These outcomes are likely mediated through inflammatory activity that alters hormones, skeletal muscle, and the immune system. Polymorphic variants in the IL-6 gene influence IL-6 expression. We hypothesized that IL-6 alleles associate with increased serum of IL-6, decreased muscle strength, and frailty, and tested this in the Women's Health and Aging cohorts. We genotyped 463 participants age 70-79, and identified three common IL-6 haplotype blocks for the Caucasian (n=363) and African American (n=100) subsets. Using linear and logistic regression, and adjusting for age, BMI, race, and osteoarthritis, we identified no significant or clinically meaningful relationship between any single IL-6 single nucleotide polymorphism (SNP) or any IL-6 haplotype and serum IL-6 level, grip, knee, or hip strength, or frailty. Given that the promoter SNP (rs1800795) has been reported to influence IL-6 levels and health outcomes, we performed a similar association study in the In Chianti population (n=266) and confirmed lack of association. These results suggest that IL-6 gene variation may not be an important factor in the determination of elevated IL-6 levels and related phenotypes found in older women.
AB - Elevated levels of the inflammatory cytokine IL-6 are associated with the development of disability, frailty, and mortality in older adults. These outcomes are likely mediated through inflammatory activity that alters hormones, skeletal muscle, and the immune system. Polymorphic variants in the IL-6 gene influence IL-6 expression. We hypothesized that IL-6 alleles associate with increased serum of IL-6, decreased muscle strength, and frailty, and tested this in the Women's Health and Aging cohorts. We genotyped 463 participants age 70-79, and identified three common IL-6 haplotype blocks for the Caucasian (n=363) and African American (n=100) subsets. Using linear and logistic regression, and adjusting for age, BMI, race, and osteoarthritis, we identified no significant or clinically meaningful relationship between any single IL-6 single nucleotide polymorphism (SNP) or any IL-6 haplotype and serum IL-6 level, grip, knee, or hip strength, or frailty. Given that the promoter SNP (rs1800795) has been reported to influence IL-6 levels and health outcomes, we performed a similar association study in the In Chianti population (n=266) and confirmed lack of association. These results suggest that IL-6 gene variation may not be an important factor in the determination of elevated IL-6 levels and related phenotypes found in older women.
KW - Aging
KW - Disability
KW - Frailty
KW - IL-6
KW - IL-6 gene variation
KW - IL-6 haplotypes
KW - Muscle strength
UR - http://www.scopus.com/inward/record.url?scp=16844384831&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=16844384831&partnerID=8YFLogxK
U2 - 10.1016/j.exger.2005.01.012
DO - 10.1016/j.exger.2005.01.012
M3 - Article
C2 - 15820616
AN - SCOPUS:16844384831
SN - 0531-5565
VL - 40
SP - 344
EP - 352
JO - Experimental Gerontology
JF - Experimental Gerontology
IS - 4
ER -