IL-4 receptor mutations

Ping Ying Pan, Paul Rothman

Research output: Contribution to journalReview articlepeer-review

Abstract

IL-4 plays an important role in regulating immune responses. Distinct signaling pathways, including those for gene activation and cell differentiation and those for cell proliferation and protection from apoptosis, are initiated from the receptor complex for IL-4 following ligand-recepior engagement. Several advances have been made in our understanding of how distinct functions of IL-4 are mediated. Most of these studies employed artificial mutations of the IL-4-receptor α chain using site-directed mutagenesis and/or deletional mutation. In addition, naturally occurring mutations of the IL-4-receptor α chain have been identified and implicated as a genetic predisposition for allergic disorders. The results of these studies suggest a modular organization of the receptor and an independent regulation of gene activation and cell growth.

Original languageEnglish (US)
Pages (from-to)615-620
Number of pages6
JournalCurrent Opinion in Immunology
Volume11
Issue number6
DOIs
StatePublished - Dec 1 1999
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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