IL-4 receptor expression on CD8+ T cells is required for the development of protective memory responses against liver stages of malaria parasites

Alexandre Morrot, Julius C.R. Hafalla, Ian A. Cockburn, Luzia H. Carvalho, Fidel Zavala

Research output: Contribution to journalArticlepeer-review

Abstract

IL-4 receptor (IL-4R)-deficient CD8+ T cells specific for the circumsporozoite protein of Plasmodium yoelii develop a severely impaired memory response after priming with parasites. Memory CD8+ T cells lacking the IL-4R are unable to establish a stable population residing in nonlymphoid organs, although they develop normally in lymphoid organs. Because memory cells from nonlymphoid organs disappear shortly after immunization, the protective antiparasitic activity of this T cell response also is lost. These results demonstrate that IL-4/IL-4R interactions on CD8+ T cells play a critical role in modulating the development and tissue distribution of memory cells induced by parasite immunization. They also indicate that memory cells residing in nonlymphoid tissues are critical for protective immunity against malaria parasites. JEM

Original languageEnglish (US)
Pages (from-to)551-560
Number of pages10
JournalJournal of Experimental Medicine
Volume202
Issue number4
DOIs
StatePublished - Aug 2005

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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