TY - JOUR
T1 - IL-11/IL11RA receptor mediated signaling
T2 - A web accessible knowledgebase
AU - Balakrishnan, Lavanya
AU - Soman, Sowmya
AU - Patil, Yatish B.
AU - Advani, Jayshree
AU - Thomas, Joji Kurian
AU - Desai, Dattatraya Venkatesh
AU - Kulkarni-Kale, Urmila
AU - Harsha, H. C.
AU - Prasad, T. S.Keshava
AU - Raju, Rajesh
AU - Pandey, Akhilesh
AU - Dimitriadis, Eva
AU - Chatterjee, Aditi
N1 - Funding Information:
We thank the Department of Biotechnology (DBT), Government of India for research support to the Institute of Bioinformatics, Bangalore. Dattatraya Venkatesh Desai and Urmila Kulkarni-Kale gratefully acknowledge the facilities of the Bioinformatics Centre, University of Pune and the “ Centre of Excellence ” grant by the Department of Biotechnology (DBT), Government of India as well as the Department of Information Technology (DIT), Government of India. HC Harsha is a Wellcome Trust/DBT India Alliance Early Career Fellow. Eva Dimitriadis was supported by the National Health and Medical Research Council (NHMRC) of Australia.
Funding Information:
Declaration of interest: The authors report no declarations of interest. The authors alone are responsible for the content and writing of the paper. The study was also supported by the Victorian Government ’s Operational Infrastructure Support Program.
PY - 2013/8
Y1 - 2013/8
N2 - Interleukin-11 (IL-11) is a pleiotropic cytokine that belongs to gp130 family. It plays a significant role in the synthesis and maturation of hematopoietic cells, inhibition of adipogenesis, regulation of embryo implantation, and trophoblasts invasion. Although IL-11 signaling has been described in several biological processes, a centralized resource documenting these molecular reactions induced by IL-11 is not publicly available. In the current study, we have manually annotated the molecular reactions and interactions induced by IL-11 from literature available. We have documented 40 unique molecules involved in 18 protein-protein interactions, 26 enzyme-substrate reactions, 7 translocation events, and 4 activation/inhibition reactions. We have also annotated 23 genes reported to be differentially regulated under IL-11 stimulation. We have enabled the data availability in standard exchange formats from 'NetPath', a repository for signaling pathways. We believe that this will help in the identification of potential therapeutic targets in IL-11-associated disorders.
AB - Interleukin-11 (IL-11) is a pleiotropic cytokine that belongs to gp130 family. It plays a significant role in the synthesis and maturation of hematopoietic cells, inhibition of adipogenesis, regulation of embryo implantation, and trophoblasts invasion. Although IL-11 signaling has been described in several biological processes, a centralized resource documenting these molecular reactions induced by IL-11 is not publicly available. In the current study, we have manually annotated the molecular reactions and interactions induced by IL-11 from literature available. We have documented 40 unique molecules involved in 18 protein-protein interactions, 26 enzyme-substrate reactions, 7 translocation events, and 4 activation/inhibition reactions. We have also annotated 23 genes reported to be differentially regulated under IL-11 stimulation. We have enabled the data availability in standard exchange formats from 'NetPath', a repository for signaling pathways. We believe that this will help in the identification of potential therapeutic targets in IL-11-associated disorders.
KW - BioPAX
KW - Gastric cancer
KW - PathVisio
KW - Placentation
KW - Thrombopoiesis
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U2 - 10.3109/15419061.2013.791683
DO - 10.3109/15419061.2013.791683
M3 - Article
C2 - 23631681
AN - SCOPUS:84881448259
VL - 20
SP - 81
EP - 86
JO - Cell Adhesion and Communication
JF - Cell Adhesion and Communication
SN - 1541-9061
IS - 3-4
ER -