IL-11/IL11RA receptor mediated signaling: A web accessible knowledgebase

Lavanya Balakrishnan, Sowmya Soman, Yatish B. Patil, Jayshree Advani, Joji Kurian Thomas, Dattatraya Venkatesh Desai, Urmila Kulkarni-Kale, H. C. Harsha, T. S Keshava Prasad, Rajesh Raju, Akhilesh Pandey, Eva Dimitriadis, Aditi Chatterjee

Research output: Contribution to journalArticle

Abstract

Interleukin-11 (IL-11) is a pleiotropic cytokine that belongs to gp130 family. It plays a significant role in the synthesis and maturation of hematopoietic cells, inhibition of adipogenesis, regulation of embryo implantation, and trophoblasts invasion. Although IL-11 signaling has been described in several biological processes, a centralized resource documenting these molecular reactions induced by IL-11 is not publicly available. In the current study, we have manually annotated the molecular reactions and interactions induced by IL-11 from literature available. We have documented 40 unique molecules involved in 18 protein-protein interactions, 26 enzyme-substrate reactions, 7 translocation events, and 4 activation/inhibition reactions. We have also annotated 23 genes reported to be differentially regulated under IL-11 stimulation. We have enabled the data availability in standard exchange formats from 'NetPath', a repository for signaling pathways. We believe that this will help in the identification of potential therapeutic targets in IL-11-associated disorders.

Original languageEnglish (US)
Pages (from-to)81-86
Number of pages6
JournalCell Communication and Adhesion
Volume20
Issue number3-4
DOIs
StatePublished - Aug 2013

Fingerprint

Interleukin-11 Receptors
Interleukin-11
Knowledge Bases
Biological Phenomena
Adipogenesis
Trophoblasts
Proteins
Genes
Chemical activation
Availability
Cytokines
Molecules
Substrates
Enzymes

Keywords

  • BioPAX
  • Gastric cancer
  • PathVisio
  • Placentation
  • Thrombopoiesis

ASJC Scopus subject areas

  • Cell Biology
  • Clinical Biochemistry

Cite this

Balakrishnan, L., Soman, S., Patil, Y. B., Advani, J., Thomas, J. K., Desai, D. V., ... Chatterjee, A. (2013). IL-11/IL11RA receptor mediated signaling: A web accessible knowledgebase. Cell Communication and Adhesion, 20(3-4), 81-86. https://doi.org/10.3109/15419061.2013.791683

IL-11/IL11RA receptor mediated signaling : A web accessible knowledgebase. / Balakrishnan, Lavanya; Soman, Sowmya; Patil, Yatish B.; Advani, Jayshree; Thomas, Joji Kurian; Desai, Dattatraya Venkatesh; Kulkarni-Kale, Urmila; Harsha, H. C.; Prasad, T. S Keshava; Raju, Rajesh; Pandey, Akhilesh; Dimitriadis, Eva; Chatterjee, Aditi.

In: Cell Communication and Adhesion, Vol. 20, No. 3-4, 08.2013, p. 81-86.

Research output: Contribution to journalArticle

Balakrishnan, L, Soman, S, Patil, YB, Advani, J, Thomas, JK, Desai, DV, Kulkarni-Kale, U, Harsha, HC, Prasad, TSK, Raju, R, Pandey, A, Dimitriadis, E & Chatterjee, A 2013, 'IL-11/IL11RA receptor mediated signaling: A web accessible knowledgebase', Cell Communication and Adhesion, vol. 20, no. 3-4, pp. 81-86. https://doi.org/10.3109/15419061.2013.791683
Balakrishnan L, Soman S, Patil YB, Advani J, Thomas JK, Desai DV et al. IL-11/IL11RA receptor mediated signaling: A web accessible knowledgebase. Cell Communication and Adhesion. 2013 Aug;20(3-4):81-86. https://doi.org/10.3109/15419061.2013.791683
Balakrishnan, Lavanya ; Soman, Sowmya ; Patil, Yatish B. ; Advani, Jayshree ; Thomas, Joji Kurian ; Desai, Dattatraya Venkatesh ; Kulkarni-Kale, Urmila ; Harsha, H. C. ; Prasad, T. S Keshava ; Raju, Rajesh ; Pandey, Akhilesh ; Dimitriadis, Eva ; Chatterjee, Aditi. / IL-11/IL11RA receptor mediated signaling : A web accessible knowledgebase. In: Cell Communication and Adhesion. 2013 ; Vol. 20, No. 3-4. pp. 81-86.
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