Abstract
Interleukin-11 (IL-11) is a pleiotropic cytokine that belongs to gp130 family. It plays a significant role in the synthesis and maturation of hematopoietic cells, inhibition of adipogenesis, regulation of embryo implantation, and trophoblasts invasion. Although IL-11 signaling has been described in several biological processes, a centralized resource documenting these molecular reactions induced by IL-11 is not publicly available. In the current study, we have manually annotated the molecular reactions and interactions induced by IL-11 from literature available. We have documented 40 unique molecules involved in 18 protein-protein interactions, 26 enzyme-substrate reactions, 7 translocation events, and 4 activation/inhibition reactions. We have also annotated 23 genes reported to be differentially regulated under IL-11 stimulation. We have enabled the data availability in standard exchange formats from 'NetPath', a repository for signaling pathways. We believe that this will help in the identification of potential therapeutic targets in IL-11-associated disorders.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 81-86 |
| Number of pages | 6 |
| Journal | Cell Communication and Adhesion |
| Volume | 20 |
| Issue number | 3-4 |
| DOIs | |
| State | Published - Aug 2013 |
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Keywords
- BioPAX
- Gastric cancer
- PathVisio
- Placentation
- Thrombopoiesis
ASJC Scopus subject areas
- Cell Biology
- Clinical Biochemistry
Cite this
IL-11/IL11RA receptor mediated signaling : A web accessible knowledgebase. / Balakrishnan, Lavanya; Soman, Sowmya; Patil, Yatish B.; Advani, Jayshree; Thomas, Joji Kurian; Desai, Dattatraya Venkatesh; Kulkarni-Kale, Urmila; Harsha, H. C.; Prasad, T. S Keshava; Raju, Rajesh; Pandey, Akhilesh; Dimitriadis, Eva; Chatterjee, Aditi.
In: Cell Communication and Adhesion, Vol. 20, No. 3-4, 08.2013, p. 81-86.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - IL-11/IL11RA receptor mediated signaling
T2 - A web accessible knowledgebase
AU - Balakrishnan, Lavanya
AU - Soman, Sowmya
AU - Patil, Yatish B.
AU - Advani, Jayshree
AU - Thomas, Joji Kurian
AU - Desai, Dattatraya Venkatesh
AU - Kulkarni-Kale, Urmila
AU - Harsha, H. C.
AU - Prasad, T. S Keshava
AU - Raju, Rajesh
AU - Pandey, Akhilesh
AU - Dimitriadis, Eva
AU - Chatterjee, Aditi
PY - 2013/8
Y1 - 2013/8
N2 - Interleukin-11 (IL-11) is a pleiotropic cytokine that belongs to gp130 family. It plays a significant role in the synthesis and maturation of hematopoietic cells, inhibition of adipogenesis, regulation of embryo implantation, and trophoblasts invasion. Although IL-11 signaling has been described in several biological processes, a centralized resource documenting these molecular reactions induced by IL-11 is not publicly available. In the current study, we have manually annotated the molecular reactions and interactions induced by IL-11 from literature available. We have documented 40 unique molecules involved in 18 protein-protein interactions, 26 enzyme-substrate reactions, 7 translocation events, and 4 activation/inhibition reactions. We have also annotated 23 genes reported to be differentially regulated under IL-11 stimulation. We have enabled the data availability in standard exchange formats from 'NetPath', a repository for signaling pathways. We believe that this will help in the identification of potential therapeutic targets in IL-11-associated disorders.
AB - Interleukin-11 (IL-11) is a pleiotropic cytokine that belongs to gp130 family. It plays a significant role in the synthesis and maturation of hematopoietic cells, inhibition of adipogenesis, regulation of embryo implantation, and trophoblasts invasion. Although IL-11 signaling has been described in several biological processes, a centralized resource documenting these molecular reactions induced by IL-11 is not publicly available. In the current study, we have manually annotated the molecular reactions and interactions induced by IL-11 from literature available. We have documented 40 unique molecules involved in 18 protein-protein interactions, 26 enzyme-substrate reactions, 7 translocation events, and 4 activation/inhibition reactions. We have also annotated 23 genes reported to be differentially regulated under IL-11 stimulation. We have enabled the data availability in standard exchange formats from 'NetPath', a repository for signaling pathways. We believe that this will help in the identification of potential therapeutic targets in IL-11-associated disorders.
KW - BioPAX
KW - Gastric cancer
KW - PathVisio
KW - Placentation
KW - Thrombopoiesis
UR - http://www.scopus.com/inward/record.url?scp=84881448259&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84881448259&partnerID=8YFLogxK
U2 - 10.3109/15419061.2013.791683
DO - 10.3109/15419061.2013.791683
M3 - Article
C2 - 23631681
AN - SCOPUS:84881448259
VL - 20
SP - 81
EP - 86
JO - Cell Communication and Adhesion
JF - Cell Communication and Adhesion
SN - 1541-9061
IS - 3-4
ER -