IL-11/IL11RA receptor mediated signaling: A web accessible knowledgebase

Lavanya Balakrishnan, Sowmya Soman, Yatish B. Patil, Jayshree Advani, Joji Kurian Thomas, Dattatraya Venkatesh Desai, Urmila Kulkarni-Kale, H. C. Harsha, T. S.Keshava Prasad, Rajesh Raju, Akhilesh Pandey, Eva Dimitriadis, Aditi Chatterjee

Research output: Contribution to journalArticlepeer-review

Abstract

Interleukin-11 (IL-11) is a pleiotropic cytokine that belongs to gp130 family. It plays a significant role in the synthesis and maturation of hematopoietic cells, inhibition of adipogenesis, regulation of embryo implantation, and trophoblasts invasion. Although IL-11 signaling has been described in several biological processes, a centralized resource documenting these molecular reactions induced by IL-11 is not publicly available. In the current study, we have manually annotated the molecular reactions and interactions induced by IL-11 from literature available. We have documented 40 unique molecules involved in 18 protein-protein interactions, 26 enzyme-substrate reactions, 7 translocation events, and 4 activation/inhibition reactions. We have also annotated 23 genes reported to be differentially regulated under IL-11 stimulation. We have enabled the data availability in standard exchange formats from 'NetPath', a repository for signaling pathways. We believe that this will help in the identification of potential therapeutic targets in IL-11-associated disorders.

Original languageEnglish (US)
Pages (from-to)81-86
Number of pages6
JournalCell Communication and Adhesion
Volume20
Issue number3-4
DOIs
StatePublished - Aug 1 2013

Keywords

  • BioPAX
  • Gastric cancer
  • PathVisio
  • Placentation
  • Thrombopoiesis

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology

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