III. Intervention in early asthma: Mast-cell responses in the development of asthma

C. O. Bingham, K. F. Austen

Research output: Contribution to journalReview articlepeer-review

Abstract

Many cells participate in the pathogenesis of asthmatic inflammation. The mast cell is localized at the interface of the internal and external environment within the lung where it may respond to allergens and other exogenous stimuli. The activation of mast cells leads to the release of mediators that contribute to the early phase of asthmatic inflammation. Mast- cell-derived products may also contribute to the late-phase asthmatic response. This review summarizes the developmental biologic features of the mast cell, its receptor-mediated activation, and its range of preformed, newly synthesized, and induced mediators that contribute to asthmatic inflammation.

Original languageEnglish (US)
Pages (from-to)S527-S534
JournalJournal of Allergy and Clinical Immunology
Volume105
Issue number2 II
StatePublished - Jan 1 2000
Externally publishedYes

Keywords

  • Asthma
  • Asthma pathogenesis
  • FcεRI
  • Inflammation
  • Mast cell
  • Mediators

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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