IgM immune complexes, lymphocytotoxins, and rheumatoid factors in renal transplant recipients with CMV disease.

W. M. Baldwin, F. H. Claas, G. W. van Gemert, M. L. Westedt, A. van Es, M. R. Daha, L. C. Paul, L. A. van Es

Research output: Contribution to journalArticle

Abstract

In studying 127 consecutive adult recipients of cadaver renal transplants, we found that the 23 patients who developed CMV disease produced IgM immune complexes as measured by a polyethyleneglycol precipitation (PEG) assay which coincided with symptoms of their illness. In addition to anti-CMV antibodies, PEG precipitated apparently non-specific antibodies such as lymphocytotoxins and rheumatoid factor (RF). The lymphocytotoxins were IgM antibodies that were not directed against HLA antigens and lysed granulocytes as well as lymphocytes but not platelets at 22 degrees C. Lymphocytotoxin production was correlated with HLA-DR 3 and 7 and with graft dysfunction during the CMV disease. The RF also were predominantly IgM antibodies that were detectable for only 3-8 weeks. The production of RF coincided with the initial rise in IgG anti-CMV antibody activity and some reacted with the Fab fragments of IgG raising the possibility that they could modulate the cellular or humoral immune response to CMV. Patients with RF tended to have severe CMV infections with pneumonia and graft dysfunction.

Original languageEnglish (US)
Pages (from-to)9-13
Number of pages5
JournalScandinavian Journal of Urology and Nephrology, Supplement
Volume92
StatePublished - 1985
Externally publishedYes

Fingerprint

Rheumatoid Factor
Antigen-Antibody Complex
Immunoglobulin M
Kidney
Transplants
Antibodies
Anti-Idiotypic Antibodies
Immunoglobulin G
Immunoglobulin Fab Fragments
HLA-DR Antigens
Humoral Immunity
HLA Antigens
Cadaver
Granulocytes
Cellular Immunity
Pneumonia
Blood Platelets
Lymphocytes
Transplant Recipients
Infection

ASJC Scopus subject areas

  • Nephrology
  • Urology

Cite this

Baldwin, W. M., Claas, F. H., van Gemert, G. W., Westedt, M. L., van Es, A., Daha, M. R., ... van Es, L. A. (1985). IgM immune complexes, lymphocytotoxins, and rheumatoid factors in renal transplant recipients with CMV disease. Scandinavian Journal of Urology and Nephrology, Supplement, 92, 9-13.

IgM immune complexes, lymphocytotoxins, and rheumatoid factors in renal transplant recipients with CMV disease. / Baldwin, W. M.; Claas, F. H.; van Gemert, G. W.; Westedt, M. L.; van Es, A.; Daha, M. R.; Paul, L. C.; van Es, L. A.

In: Scandinavian Journal of Urology and Nephrology, Supplement, Vol. 92, 1985, p. 9-13.

Research output: Contribution to journalArticle

Baldwin, WM, Claas, FH, van Gemert, GW, Westedt, ML, van Es, A, Daha, MR, Paul, LC & van Es, LA 1985, 'IgM immune complexes, lymphocytotoxins, and rheumatoid factors in renal transplant recipients with CMV disease.', Scandinavian Journal of Urology and Nephrology, Supplement, vol. 92, pp. 9-13.
Baldwin, W. M. ; Claas, F. H. ; van Gemert, G. W. ; Westedt, M. L. ; van Es, A. ; Daha, M. R. ; Paul, L. C. ; van Es, L. A. / IgM immune complexes, lymphocytotoxins, and rheumatoid factors in renal transplant recipients with CMV disease. In: Scandinavian Journal of Urology and Nephrology, Supplement. 1985 ; Vol. 92. pp. 9-13.
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AU - van Es, A.

AU - Daha, M. R.

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