Abstract
Objective. Antibodies to β 2 glycoprotein I (IgG and IgM isotypes) have recently been added to the laboratory criteria of the revised antiphospholipid syndrome classification criteria. We investigated whether IgM anti-β 2-glycoprotein I (anti-β 2-GPI) is associated with clinical manifestations of systemic lupus erythematosus (SLE). Methods. Anti-β 2-GPI was measured in 796 patients with SLE (93% women, 53% white, 38% African American, mean age 45 yrs). IgM anti-β 2-GPI (> 20 phospholipid units) was found in 16%. Associations were determined with clinical manifestations of SLE and with components of the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index. Results. As expected, IgM anti-β 2-GPI was highly associated with both the lupus anticoagulant and with anticardiolipin. It was associated with transient ischemic attack (OR 2.64, p = 0.04), but not significantly with venous or arterial thrombosis. IgM anti-β 2-GPI was protective against lupus nephritis (OR 0.54, p = 0.049), renal damage (p = 0.019), and hypertension (OR 0.58, p = 0.008). This protective effect remained after adjustment for ethnicity. Conclusion. In SLE, IgM anti-β 2-GPI is not associated with thrombosis but is protective against lupus nephritis and renal damage. "Natural" autoantibodies of the IgM isotype may have a protective effect. The Journal of Rheumatology
Original language | English (US) |
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Pages (from-to) | 450-453 |
Number of pages | 4 |
Journal | Journal of Rheumatology |
Volume | 38 |
Issue number | 3 |
DOIs | |
State | Published - Mar 2011 |
Keywords
- Anti-β glycoprotein I
- Antiphospholipid antibodies
- Lupus nephritis
- Systemic lupus erythematosus
ASJC Scopus subject areas
- Rheumatology
- Immunology and Allergy
- Immunology