IgG transport across mucosal barriers by neonatal Fc receptor for IgG and mucosal immunity

Masaru Yoshida, Atsuhiro Masuda, Timothy T. Kuo, Kanna Kobayashi, Steven M. Claypool, Tetsuya Takagawa, Hiromu Kutsumi, Takeshi Azuma, Wayne I. Lencer, Richard S. Blumberg

Research output: Contribution to journalReview articlepeer-review

Abstract

Mucosal secretions of the human gastrointestinal, respiratory, and genital tracts contain significant quantities of IgG. The neonatal Fc receptor for IgG (FcRn) plays a major role in regulating host IgG levels and transporting IgG and associated antigens across polarized epithelial barriers. The FcRn can then recycle the IgG/antigen complex back across the intestinal barrier into the lamina propria for processing by dendritic cells and presentation to CD4 + T cells in regional organized lymphoid structures. FcRn, through its ability to secrete and absorb IgG, thus integrates luminal antigen encounters with systemic immune compartments and, as such, provides essential host defense and immunoregulatory functions at the mucosal surfaces.

Original languageEnglish (US)
Pages (from-to)397-403
Number of pages7
JournalSpringer Seminars in Immunopathology
Volume28
Issue number4
DOIs
StatePublished - Dec 2006
Externally publishedYes

Keywords

  • CD4 T cells
  • Dendritic cells
  • Immune complex
  • Transcytosis

ASJC Scopus subject areas

  • Immunology

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