IgD-binding factors from mouse T lymphocytes

M. Adachi, K. Ishizaka

Research output: Contribution to journalArticle

Abstract

Incubation of normal mouse splenic lymphocytes with dimeric mouse IgD results in the formation of T-cell factors that selectively inhibit rosette formation of Fcδ receptor-positive lymphocytes with IgD-coated erythrocytes. The rosette-inhibiting factors bound to IgD-sepharose and were recovered by elution at acid pH. The results indicate that the rosette-inhibiting factors are IgD-binding factors. Neither IgE-binding factors nor IgD-binding factors inhibited IgD rosettes. The IgD-binding factors induced by IgD consist of two species of molecular weight 78,000 and 37,000, respectively. The source of IgD-binding factors is Lyt-1+ T cells bearing Fcδ receptors on the T cells induces the formation of IgD-binding factors.

Original languageEnglish (US)
Pages (from-to)7003-7007
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume83
Issue number18
DOIs
StatePublished - Jan 1 1986

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