IFN-α2b increases interleukin-10 expression in primary activated human CD8+ T cells

Sabrina Curreli, Fabio Romerio, Paola Secchiero, Davide Zella

Research output: Contribution to journalArticlepeer-review

Abstract

Interleukin-10 (IL-10) is a multifunctional cytokine with diverse effects on most hematopoietic cell types. It appears the principal function of IL-10 is to limit and ultimately terminate inflammatory response. We demonstrate here that interferon-α2b (IFN-α) increases the expression of IL-10 in activated primary CD8+ T cells. Optimal induction of mRNA expression and protein synthesis was observed when IFN-α was added to cells activated by the combination of anti-CD3 monoclonal antibody (mAb) and IL-2. Maximal stimulation of IL-10 protein production was observed after prolonged incubation periods (48-72 h). No effects were observed on the production of IL-4, whereas IFN-γ was produced with a faster kinetics than an untreated control. Our data indicate that IFN-α promotes the development of a CD8+ T cell population with enhanced anti-inflammatory activity, which may play a critical role in the regulation of a proper immune response.

Original languageEnglish (US)
Pages (from-to)1167-1173
Number of pages7
JournalJournal of Interferon and Cytokine Research
Volume22
Issue number12
DOIs
StatePublished - Dec 1 2002
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Cell Biology
  • Virology

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