TY - JOUR
T1 - IDO-mediated tryptophan degradation in the pathogenesis of malignant tumor disease
AU - Sucher, Robert
AU - Kurz, Katharina
AU - Weiss, Guenter
AU - Margreiter, Raimund
AU - Fuchs, Dietmar
AU - Brandacher, Gerald
PY - 2010
Y1 - 2010
N2 - Immune escape is a fundamental trait of cancer in which the Th1-type cytokine interferon- γ (IFN-γ) seems to play a key role. Among other tumoricidal biochemical pathways, IFN-γ induces the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO) in a variety of cells including macrophages, dendritic cells (DCs) and tumor cells. IDO activity has been shown to reflect the extent and the course in a plethora of malignancies including prostate, colorectal, pancreatic, cervical, endometrial, gastric, lung, bladder, ovarian, esophageal and renal cell carcinomas, glioblastomas, mesotheliomas, and melanomas. Furthermore IDO activity during malignant tumor diseases seems to be part of the tumoricidal immune defense strategy, which in the long run is detrimental to the host, when tryptophan deprivation and production of pro-apoptotic tryptophan catabolites counteract T-cell responsiveness.
AB - Immune escape is a fundamental trait of cancer in which the Th1-type cytokine interferon- γ (IFN-γ) seems to play a key role. Among other tumoricidal biochemical pathways, IFN-γ induces the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO) in a variety of cells including macrophages, dendritic cells (DCs) and tumor cells. IDO activity has been shown to reflect the extent and the course in a plethora of malignancies including prostate, colorectal, pancreatic, cervical, endometrial, gastric, lung, bladder, ovarian, esophageal and renal cell carcinomas, glioblastomas, mesotheliomas, and melanomas. Furthermore IDO activity during malignant tumor diseases seems to be part of the tumoricidal immune defense strategy, which in the long run is detrimental to the host, when tryptophan deprivation and production of pro-apoptotic tryptophan catabolites counteract T-cell responsiveness.
KW - IDO
KW - Malignant tumor disease
KW - Tryptophan
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U2 - 10.4137/ijtr.s4157
DO - 10.4137/ijtr.s4157
M3 - Review article
AN - SCOPUS:84859833114
SN - 1178-6469
VL - 3
SP - 113
EP - 120
JO - International Journal of Tryptophan Research
JF - International Journal of Tryptophan Research
IS - 1
ER -