Idiopathic genital ulcers in women infected with human immunodeficiency virus

Jean Anderson, Rebecca A. Clark, D. Heather Watts, Michele Till, Concepcion Arrastia, Paula Schuman, Susan E. Cohn, Mary Young, Laura Bessen, Ruth Greenblatt, Mary Vogler, Susan Swindells, Pam Boyer

Research output: Contribution to journalArticle

Abstract

A national survey of investigators caring for human immunodeficiency virus (HIV)-infected women was undertaken to describe the clinical presentation of idiopathic genital ulcer disease. Patients with negative syphilis and herpes simplex testing and/or negative genital ulcer biopsy were included in this study. Study participants (n = 29) were generally severely immunocompromised (median CD4 cell count was 50/mm3, and 68% had an acquired immunodeficiency syndrome [AIDS]-defining opportunistic process). Thirty- seven percent had coexistent oral ulcers and 19% had their genital ulcer progress to fistula formation (four rectovaginal and one vaginal-perineal). There was generally a favorable response to topical, systemic, and intralesional steroid treatment. This study suggests that idiopathic or probable aphthous genital ulcers in women have similar clinical characteristics to aphthous oroesophageal ulcers. Although infrequent, these genital ulcers can cause severe morbidity. Further research is warranted to better define the pathophysiology and optimal management.

Original languageEnglish (US)
Pages (from-to)343-347
Number of pages5
JournalJournal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Volume13
Issue number4
StatePublished - 1996

Fingerprint

Ulcer
HIV
Aphthous Stomatitis
Oral Ulcer
Herpes Simplex
Syphilis
CD4 Lymphocyte Count
Fistula
Acquired Immunodeficiency Syndrome
Steroids
Research Personnel
Morbidity
Biopsy
Research
Therapeutics

Keywords

  • Aphthous ulcers
  • Genital ulcer disease
  • HIV-infected women

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Virology

Cite this

Anderson, J., Clark, R. A., Watts, D. H., Till, M., Arrastia, C., Schuman, P., ... Boyer, P. (1996). Idiopathic genital ulcers in women infected with human immunodeficiency virus. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, 13(4), 343-347.

Idiopathic genital ulcers in women infected with human immunodeficiency virus. / Anderson, Jean; Clark, Rebecca A.; Watts, D. Heather; Till, Michele; Arrastia, Concepcion; Schuman, Paula; Cohn, Susan E.; Young, Mary; Bessen, Laura; Greenblatt, Ruth; Vogler, Mary; Swindells, Susan; Boyer, Pam.

In: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, Vol. 13, No. 4, 1996, p. 343-347.

Research output: Contribution to journalArticle

Anderson, J, Clark, RA, Watts, DH, Till, M, Arrastia, C, Schuman, P, Cohn, SE, Young, M, Bessen, L, Greenblatt, R, Vogler, M, Swindells, S & Boyer, P 1996, 'Idiopathic genital ulcers in women infected with human immunodeficiency virus', Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, vol. 13, no. 4, pp. 343-347.
Anderson, Jean ; Clark, Rebecca A. ; Watts, D. Heather ; Till, Michele ; Arrastia, Concepcion ; Schuman, Paula ; Cohn, Susan E. ; Young, Mary ; Bessen, Laura ; Greenblatt, Ruth ; Vogler, Mary ; Swindells, Susan ; Boyer, Pam. / Idiopathic genital ulcers in women infected with human immunodeficiency virus. In: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology. 1996 ; Vol. 13, No. 4. pp. 343-347.
@article{b98ad035d8bc4be283c234e6c51070ed,
title = "Idiopathic genital ulcers in women infected with human immunodeficiency virus",
abstract = "A national survey of investigators caring for human immunodeficiency virus (HIV)-infected women was undertaken to describe the clinical presentation of idiopathic genital ulcer disease. Patients with negative syphilis and herpes simplex testing and/or negative genital ulcer biopsy were included in this study. Study participants (n = 29) were generally severely immunocompromised (median CD4 cell count was 50/mm3, and 68{\%} had an acquired immunodeficiency syndrome [AIDS]-defining opportunistic process). Thirty- seven percent had coexistent oral ulcers and 19{\%} had their genital ulcer progress to fistula formation (four rectovaginal and one vaginal-perineal). There was generally a favorable response to topical, systemic, and intralesional steroid treatment. This study suggests that idiopathic or probable aphthous genital ulcers in women have similar clinical characteristics to aphthous oroesophageal ulcers. Although infrequent, these genital ulcers can cause severe morbidity. Further research is warranted to better define the pathophysiology and optimal management.",
keywords = "Aphthous ulcers, Genital ulcer disease, HIV-infected women",
author = "Jean Anderson and Clark, {Rebecca A.} and Watts, {D. Heather} and Michele Till and Concepcion Arrastia and Paula Schuman and Cohn, {Susan E.} and Mary Young and Laura Bessen and Ruth Greenblatt and Mary Vogler and Susan Swindells and Pam Boyer",
year = "1996",
language = "English (US)",
volume = "13",
pages = "343--347",
journal = "Journal of Acquired Immune Deficiency Syndromes",
issn = "1525-4135",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Idiopathic genital ulcers in women infected with human immunodeficiency virus

AU - Anderson, Jean

AU - Clark, Rebecca A.

AU - Watts, D. Heather

AU - Till, Michele

AU - Arrastia, Concepcion

AU - Schuman, Paula

AU - Cohn, Susan E.

AU - Young, Mary

AU - Bessen, Laura

AU - Greenblatt, Ruth

AU - Vogler, Mary

AU - Swindells, Susan

AU - Boyer, Pam

PY - 1996

Y1 - 1996

N2 - A national survey of investigators caring for human immunodeficiency virus (HIV)-infected women was undertaken to describe the clinical presentation of idiopathic genital ulcer disease. Patients with negative syphilis and herpes simplex testing and/or negative genital ulcer biopsy were included in this study. Study participants (n = 29) were generally severely immunocompromised (median CD4 cell count was 50/mm3, and 68% had an acquired immunodeficiency syndrome [AIDS]-defining opportunistic process). Thirty- seven percent had coexistent oral ulcers and 19% had their genital ulcer progress to fistula formation (four rectovaginal and one vaginal-perineal). There was generally a favorable response to topical, systemic, and intralesional steroid treatment. This study suggests that idiopathic or probable aphthous genital ulcers in women have similar clinical characteristics to aphthous oroesophageal ulcers. Although infrequent, these genital ulcers can cause severe morbidity. Further research is warranted to better define the pathophysiology and optimal management.

AB - A national survey of investigators caring for human immunodeficiency virus (HIV)-infected women was undertaken to describe the clinical presentation of idiopathic genital ulcer disease. Patients with negative syphilis and herpes simplex testing and/or negative genital ulcer biopsy were included in this study. Study participants (n = 29) were generally severely immunocompromised (median CD4 cell count was 50/mm3, and 68% had an acquired immunodeficiency syndrome [AIDS]-defining opportunistic process). Thirty- seven percent had coexistent oral ulcers and 19% had their genital ulcer progress to fistula formation (four rectovaginal and one vaginal-perineal). There was generally a favorable response to topical, systemic, and intralesional steroid treatment. This study suggests that idiopathic or probable aphthous genital ulcers in women have similar clinical characteristics to aphthous oroesophageal ulcers. Although infrequent, these genital ulcers can cause severe morbidity. Further research is warranted to better define the pathophysiology and optimal management.

KW - Aphthous ulcers

KW - Genital ulcer disease

KW - HIV-infected women

UR - http://www.scopus.com/inward/record.url?scp=10544255346&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=10544255346&partnerID=8YFLogxK

M3 - Article

VL - 13

SP - 343

EP - 347

JO - Journal of Acquired Immune Deficiency Syndromes

JF - Journal of Acquired Immune Deficiency Syndromes

SN - 1525-4135

IS - 4

ER -