Idiopathic chondrolysis condition in two young, wild-caught cynomolgus monkeys (Macaca fascicularis) reared in captivity

S. Rao; M. Bryant; R. Herbert; N. Sullivan; C. Murray; J. Bacher; N. Safdar

doi:10.1354/vp.08-VP-0216-R-BC

Idiopathic chondrolysis condition in two young, wild-caught cynomolgus monkeys (Macaca fascicularis) reared in captivity

S. Rao, M. Bryant, R. Herbert, N. Sullivan, C. Murray, J. Bacher, N. Safdar

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Idiopathic chondrolysis is a human clinical entity typically reported in adolescent individuals. In this brief communication, we report 2 cases of presumptive idiopathic chondrolysis of the femoral head in Cynomolgus macaques and discuss the clinical symptomatology and pathology of the disease. In detail, we describe the histomorphologic changes of idiopathic chondrolysis and compare these findings with those typically observed in the primary differential diagnoses of Legg-Calve-Perthes disease and nonspecific osteoarthritis. Consideration of this entity among differential diagnoses in young Cynomolgus macaques with unilateral osteoarthritis could be important both for laboratory animal veterinarians and pathologists.

Original language	English (US)
Pages (from-to)	509-513
Number of pages	5
Journal	Veterinary pathology
Volume	46
Issue number	3
DOIs	https://doi.org/10.1354/vp.08-VP-0216-R-BC
State	Published - May 2009
Externally published	Yes

Keywords

Cynomolgus monkey
Femoral head degenerative joint disease
Idiopathic chondrolysis
Legg-calve-perthes
Macaque
Osteoarthritis

ASJC Scopus subject areas

General Veterinary

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10.1354/vp.08-VP-0216-R-BC

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@article{277388818e1c446789c9353293868656,

title = "Idiopathic chondrolysis condition in two young, wild-caught cynomolgus monkeys (Macaca fascicularis) reared in captivity",

abstract = "Idiopathic chondrolysis is a human clinical entity typically reported in adolescent individuals. In this brief communication, we report 2 cases of presumptive idiopathic chondrolysis of the femoral head in Cynomolgus macaques and discuss the clinical symptomatology and pathology of the disease. In detail, we describe the histomorphologic changes of idiopathic chondrolysis and compare these findings with those typically observed in the primary differential diagnoses of Legg-Calve-Perthes disease and nonspecific osteoarthritis. Consideration of this entity among differential diagnoses in young Cynomolgus macaques with unilateral osteoarthritis could be important both for laboratory animal veterinarians and pathologists.",

keywords = "Cynomolgus monkey, Femoral head degenerative joint disease, Idiopathic chondrolysis, Legg-calve-perthes, Macaque, Osteoarthritis",

author = "S. Rao and M. Bryant and R. Herbert and N. Sullivan and C. Murray and J. Bacher and N. Safdar",

note = "Funding Information: We gratefully acknowledge the contributions of Ms. Alyse Zajac for manuscript coordination and preparation. We also gratefully acknowledge the contributions of Mr. Alphie Cisar for providing animal care; Ms. Brenda Hartman for figure formatting; Ms. Alida Ault, Mr. John-Paul Todd, and Ms. Linda Bessacque for scheduling and technical assistance; Mr. Jorge Chavez and Mr. Erik Lasker for providing gross photographs; Ms. Annie Merriweather and Ms. Kathy Dukes for preparation of histologic tissue sections; and Mr. Rick Dreyfuss for preparation of histologic photographs. This research was supported in part by the Intramural Research Program of the NIH, Vaccine Research Center.",

year = "2009",

month = may,

doi = "10.1354/vp.08-VP-0216-R-BC",

language = "English (US)",

volume = "46",

pages = "509--513",

journal = "Veterinary pathology",

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T1 - Idiopathic chondrolysis condition in two young, wild-caught cynomolgus monkeys (Macaca fascicularis) reared in captivity

AU - Rao, S.

AU - Bryant, M.

AU - Herbert, R.

AU - Sullivan, N.

AU - Murray, C.

AU - Bacher, J.

AU - Safdar, N.

N1 - Funding Information: We gratefully acknowledge the contributions of Ms. Alyse Zajac for manuscript coordination and preparation. We also gratefully acknowledge the contributions of Mr. Alphie Cisar for providing animal care; Ms. Brenda Hartman for figure formatting; Ms. Alida Ault, Mr. John-Paul Todd, and Ms. Linda Bessacque for scheduling and technical assistance; Mr. Jorge Chavez and Mr. Erik Lasker for providing gross photographs; Ms. Annie Merriweather and Ms. Kathy Dukes for preparation of histologic tissue sections; and Mr. Rick Dreyfuss for preparation of histologic photographs. This research was supported in part by the Intramural Research Program of the NIH, Vaccine Research Center.

PY - 2009/5

Y1 - 2009/5

N2 - Idiopathic chondrolysis is a human clinical entity typically reported in adolescent individuals. In this brief communication, we report 2 cases of presumptive idiopathic chondrolysis of the femoral head in Cynomolgus macaques and discuss the clinical symptomatology and pathology of the disease. In detail, we describe the histomorphologic changes of idiopathic chondrolysis and compare these findings with those typically observed in the primary differential diagnoses of Legg-Calve-Perthes disease and nonspecific osteoarthritis. Consideration of this entity among differential diagnoses in young Cynomolgus macaques with unilateral osteoarthritis could be important both for laboratory animal veterinarians and pathologists.

AB - Idiopathic chondrolysis is a human clinical entity typically reported in adolescent individuals. In this brief communication, we report 2 cases of presumptive idiopathic chondrolysis of the femoral head in Cynomolgus macaques and discuss the clinical symptomatology and pathology of the disease. In detail, we describe the histomorphologic changes of idiopathic chondrolysis and compare these findings with those typically observed in the primary differential diagnoses of Legg-Calve-Perthes disease and nonspecific osteoarthritis. Consideration of this entity among differential diagnoses in young Cynomolgus macaques with unilateral osteoarthritis could be important both for laboratory animal veterinarians and pathologists.

KW - Cynomolgus monkey

KW - Femoral head degenerative joint disease

KW - Idiopathic chondrolysis

KW - Legg-calve-perthes

KW - Macaque

KW - Osteoarthritis

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Idiopathic chondrolysis condition in two young, wild-caught cynomolgus monkeys (Macaca fascicularis) reared in captivity

Abstract

Keywords

ASJC Scopus subject areas

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