IDH1 and IDH2: Not Your Typical Oncogenes

Zachary J. Reitman, D. Williams Parsons, Hai Yan

Research output: Contribution to journalShort surveypeer-review


Oncogenes usually increase their normal function when activated. However, seemingly oncogenic mutations in IDH1 and IDH2 reduce their native enzyme activity. In this issue of Cancer Cell, Ward et al. pin down a neomorphic enzyme activity as a possible oncogenic function for these alterations.

Original languageEnglish (US)
Pages (from-to)215-216
Number of pages2
JournalCancer cell
Issue number3
StatePublished - Mar 16 2010

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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