IDH1 and IDH2: Not Your Typical Oncogenes

Zachary J. Reitman; D. Williams Parsons; Hai Yan

doi:10.1016/j.ccr.2010.02.024

IDH1 and IDH2: Not Your Typical Oncogenes

Zachary J. Reitman, D. Williams Parsons, Hai Yan

School of Medicine

Research output: Contribution to journal › Short survey › peer-review

Abstract

Oncogenes usually increase their normal function when activated. However, seemingly oncogenic mutations in IDH1 and IDH2 reduce their native enzyme activity. In this issue of Cancer Cell, Ward et al. pin down a neomorphic enzyme activity as a possible oncogenic function for these alterations.

Original language	English (US)
Pages (from-to)	215-216
Number of pages	2
Journal	Cancer cell
Volume	17
Issue number	3
DOIs	https://doi.org/10.1016/j.ccr.2010.02.024
State	Published - Mar 16 2010

ASJC Scopus subject areas

Oncology
Cell Biology
Cancer Research

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title = "IDH1 and IDH2: Not Your Typical Oncogenes",

abstract = "Oncogenes usually increase their normal function when activated. However, seemingly oncogenic mutations in IDH1 and IDH2 reduce their native enzyme activity. In this issue of Cancer Cell, Ward et al. pin down a neomorphic enzyme activity as a possible oncogenic function for these alterations.",

author = "Reitman, {Zachary J.} and Parsons, {D. Williams} and Hai Yan",

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AB - Oncogenes usually increase their normal function when activated. However, seemingly oncogenic mutations in IDH1 and IDH2 reduce their native enzyme activity. In this issue of Cancer Cell, Ward et al. pin down a neomorphic enzyme activity as a possible oncogenic function for these alterations.

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