Identifying statin-associated autoimmune necrotizing myopathy

Research output: Contribution to journalArticle

Abstract

Statins up-regulate expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), the rate-limiting enzyme in cholesterol synthesis and the major target of autoantibodies in statin-associated immune-mediated necrotizing myopathy. As muscle cells regenerate, they express high levels of HMGCR, which may sustain the immune response even after statin therapy is stopped. Awareness of this entity will help physicians who prescribe statins to take action to limit the associated morbidity.

Original languageEnglish (US)
Pages (from-to)736-741
Number of pages6
JournalCleveland Clinic Journal of Medicine
Volume81
Issue number12
DOIs
StatePublished - 2014

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Hydroxymethylglutaryl-CoA Reductase Inhibitors
Muscular Diseases
Oxidoreductases
Autoantibodies
Muscle Cells
Up-Regulation
Cholesterol
Morbidity
Physicians
Enzymes
3-hydroxy-3-methylglutaryl-coenzyme A
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Identifying statin-associated autoimmune necrotizing myopathy. / Albayda, Jemima; Christopher-Stine, Lisa.

In: Cleveland Clinic Journal of Medicine, Vol. 81, No. 12, 2014, p. 736-741.

Research output: Contribution to journalArticle

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