Identifying preliminary domains to detect and measure rheumatoid arthritis flares: Report of the OMERACT 10 RA Flare Workshop

Clifton Bingham, Rieke Alten, Susan J. Bartlett, Vivian P. Bykerk, Peter M. Brooks, Ernest Choy, Robin Christensen, Daniel E. Furst, Sarah E. Hewlett, Amye Leong, James E. May, Pam Montie, Christof Pohl, Tessa C. Sanderson, Vibeke Strand, Thasia G. Woodworth

Research output: Contribution to journalArticle

Abstract

Background. While disease flares in rheumatoid arthritis (RA) are a recognized aspect of the disease process, there is limited formative research to describe them. Methods. The Outcome Measures in Rheumatology Clinical Trials (OMERACT) RA Flare Definition Working Group is conducting an international research project to understand the specific characteristics and impact of episodic disease worsening, or "flare," so that outcome measures can be developed or modified to reflect this uncommonly measured, but very real and sometimes disabling RA disease feature. Patient research partners provided critical insights into the multidimensional nature of flare. The perspectives of patients and healthcare and research professionals are being integrated to ensure that any outcome measurement to detect flares fulfills the first OMERACT criteria of Truth. Through an iterative data-driven Delphi process, a preliminary list of key domains has been identified to evaluate flare. Results. At OMERACT 10, consensus was achieved identifying features of flare in addition to the existing core set for RA, including fatigue, stiffness, symptom persistence, systemic features, and participation. Patient self-report of flare was identified as a component of the research agenda needed to establish criterion validity for a flare definition; this can be used in prospective studies to further evaluate the Discrimination and Feasibility components of the OMERACT filter for a flare outcome measure. Conclusion. Our work to date has provided better understanding of key aspects of the RA disease process as episodic, potentially disabling disease worsening even when a patient is in low disease activity. It also highlights the importance of developing ways to enhance communication between patients and clinicians and improve the ability to achieve "tight control" of disease. The Journal of Rheumatology

Original languageEnglish (US)
Pages (from-to)1751-1758
Number of pages8
JournalJournal of Rheumatology
Volume38
Issue number8
DOIs
StatePublished - Aug 2011

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Rheumatology
Rheumatoid Arthritis
Outcome Assessment (Health Care)
Clinical Trials
Education
Research
Aptitude
Health Services Research
Self Report
Fatigue
Consensus
Communication
Prospective Studies

Keywords

  • Disease activity
  • Outcome assessment
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy

Cite this

Identifying preliminary domains to detect and measure rheumatoid arthritis flares : Report of the OMERACT 10 RA Flare Workshop. / Bingham, Clifton; Alten, Rieke; Bartlett, Susan J.; Bykerk, Vivian P.; Brooks, Peter M.; Choy, Ernest; Christensen, Robin; Furst, Daniel E.; Hewlett, Sarah E.; Leong, Amye; May, James E.; Montie, Pam; Pohl, Christof; Sanderson, Tessa C.; Strand, Vibeke; Woodworth, Thasia G.

In: Journal of Rheumatology, Vol. 38, No. 8, 08.2011, p. 1751-1758.

Research output: Contribution to journalArticle

Bingham, C, Alten, R, Bartlett, SJ, Bykerk, VP, Brooks, PM, Choy, E, Christensen, R, Furst, DE, Hewlett, SE, Leong, A, May, JE, Montie, P, Pohl, C, Sanderson, TC, Strand, V & Woodworth, TG 2011, 'Identifying preliminary domains to detect and measure rheumatoid arthritis flares: Report of the OMERACT 10 RA Flare Workshop', Journal of Rheumatology, vol. 38, no. 8, pp. 1751-1758. https://doi.org/10.3899/jrheum.110401
Bingham, Clifton ; Alten, Rieke ; Bartlett, Susan J. ; Bykerk, Vivian P. ; Brooks, Peter M. ; Choy, Ernest ; Christensen, Robin ; Furst, Daniel E. ; Hewlett, Sarah E. ; Leong, Amye ; May, James E. ; Montie, Pam ; Pohl, Christof ; Sanderson, Tessa C. ; Strand, Vibeke ; Woodworth, Thasia G. / Identifying preliminary domains to detect and measure rheumatoid arthritis flares : Report of the OMERACT 10 RA Flare Workshop. In: Journal of Rheumatology. 2011 ; Vol. 38, No. 8. pp. 1751-1758.
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