Identifying miRNA-mediated signaling subpathways by integrating paired miRNA/mRNA expression data with pathway topology

Aristidis G. Vrahatis; Georgios N. Dimitrakopoulos; Athanasios K. Tsakalidis; Anastasios Bezerianos

doi:10.1109/EMBC.2015.7319270

Identifying miRNA-mediated signaling subpathways by integrating paired miRNA/mRNA expression data with pathway topology

Aristidis G. Vrahatis, Georgios N. Dimitrakopoulos, Athanasios K. Tsakalidis, Anastasios Bezerianos

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

9 Scopus citations

Abstract

In the road for network medicine the newly emerged systems-level subpathway-based analysis methods offer new disease genes, drug targets and network-based biomarkers. In parallel, paired miRNA/mRNA expression data enable simultaneously monitoring of the micronome effect upon the signaling pathways. Towards this orientation, we present a methodological pipeline for the identification of differentially expressed subpathways along with their miRNA regulators by using KEGG signaling pathway maps, miRNA-target interactions and expression profiles from paired miRNA/mRNA experiments. Our pipeline offered new biological insights on a real application of paired miRNA/mRNA expression profiles with respect to the dynamic changes from colostrum to mature milk whey; several literature supported genes and miRNAs were recontextualized through miRNA-mediated differentially expressed subpathways.

Original language	English (US)
Title of host publication	2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	3997-4000
Number of pages	4
ISBN (Electronic)	9781424492718
DOIs	https://doi.org/10.1109/EMBC.2015.7319270
State	Published - Nov 4 2015
Event	37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015 - Milan, Italy Duration: Aug 25 2015 → Aug 29 2015

Publication series

Name	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Volume	2015-November
ISSN (Print)	1557-170X

Other

Other	37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015
Country/Territory	Italy
City	Milan
Period	8/25/15 → 8/29/15

ASJC Scopus subject areas

Signal Processing
Biomedical Engineering
Computer Vision and Pattern Recognition
Health Informatics

Access to Document

10.1109/EMBC.2015.7319270

Cite this

Vrahatis, A. G., Dimitrakopoulos, G. N., Tsakalidis, A. K., & Bezerianos, A. (2015). Identifying miRNA-mediated signaling subpathways by integrating paired miRNA/mRNA expression data with pathway topology. In 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015 (pp. 3997-4000). Article 7319270 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; Vol. 2015-November). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2015.7319270

Identifying miRNA-mediated signaling subpathways by integrating paired miRNA/mRNA expression data with pathway topology. / Vrahatis, Aristidis G.; Dimitrakopoulos, Georgios N.; Tsakalidis, Athanasios K. et al.
2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015. Institute of Electrical and Electronics Engineers Inc., 2015. p. 3997-4000 7319270 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; Vol. 2015-November).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Vrahatis, AG, Dimitrakopoulos, GN, Tsakalidis, AK & Bezerianos, A 2015, Identifying miRNA-mediated signaling subpathways by integrating paired miRNA/mRNA expression data with pathway topology. in 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015., 7319270, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, vol. 2015-November, Institute of Electrical and Electronics Engineers Inc., pp. 3997-4000, 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015, Milan, Italy, 8/25/15. https://doi.org/10.1109/EMBC.2015.7319270

Vrahatis AG, Dimitrakopoulos GN, Tsakalidis AK, Bezerianos A. Identifying miRNA-mediated signaling subpathways by integrating paired miRNA/mRNA expression data with pathway topology. In 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015. Institute of Electrical and Electronics Engineers Inc. 2015. p. 3997-4000. 7319270. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). doi: 10.1109/EMBC.2015.7319270

Vrahatis, Aristidis G. ; Dimitrakopoulos, Georgios N. ; Tsakalidis, Athanasios K. et al. / Identifying miRNA-mediated signaling subpathways by integrating paired miRNA/mRNA expression data with pathway topology. 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015. Institute of Electrical and Electronics Engineers Inc., 2015. pp. 3997-4000 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

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Identifying miRNA-mediated signaling subpathways by integrating paired miRNA/mRNA expression data with pathway topology

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