Identifying glioblastoma margins using dual-targeted organic nanoparticles for efficient: In vivo fluorescence image-guided photothermal therapy

Xiaolei Cai, Aishwarya Bandla, Chan Kim Chuan, Gayathiri Magarajah, Lun De Liao, Daniel Boon Loong Teh, Brian K. Kennedy, Nitish V Thakor, Bin Liu

Research output: Contribution to journalArticle

Abstract

Current therapeutics for glioblastoma multiforme (GBM) treatment are unsatisfactory due to their limited ability to control the progression from tumour margins. In this work, organic nanoparticles (NPs) are synthesized by co-encapsulating a fluorogen with aggregation-induced emission to generate a bright red emission for imaging and a semiconducting polymer to offer NIR absorption for photothermal therapy. The NPs are further modified with different ratios of two targeting ligands, folate and cRGD peptide. The best ratio that performs specific and efficient GBM targeting is screened out through in vitro and ex vivo fluorescence imaging analysis. The NPs with an FA to cRGD ratio of 25 : 75 exhibit superior ability to target GBM cells in vitro and also show efficient accumulation at the GBM margin and in the tumour interior after in vivo administration. The progression of GBM can be greatly suppressed through photothermal therapy, which provides a simple but promising strategy for GBM treatment.

Original languageEnglish (US)
Pages (from-to)311-317
Number of pages7
JournalMaterials Horizons
Volume6
Issue number2
DOIs
Publication statusPublished - Feb 1 2019
Externally publishedYes

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ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Process Chemistry and Technology
  • Electrical and Electronic Engineering

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