Identifying Better Outcome Measures to Improve Treatment of Agitation in Dementia: A Report from the EU/US/CTAD Task Force

M. Sano, M. Soto, M. Carrillo, J. Cummings, S. Hendrix, J. Mintzer, A. Porsteinsson, P. Rosenberg, L. Schneider, J. Touchon, P. Aisen, B. Vellas, C. Lyketsos

Research output: Contribution to journalArticle

Abstract

For the second time in the past 3 years, the EU-US CTAD Task Force addressed challenges related to designing clinical trials for agitation in dementia, which is one of the most disruptive aspects of the condition for both patients and caregivers. Six recommendations emerged from the Task Force meeting: 1 - Operationalizing agitation criteria established by the IPA; 2 - Combining clinician- and caregiver-derived outcomes as primary outcome measures; 3 - Using global ratings to define clinically meaningful effects and power studies; 4 - Improving the accuracy of caregiver reports by better training and education of caregivers; 5 - Employing emerging technologies to collect near real-time behavioral data; and 6 - Utilizing innovative trial designs and increasing the use of biomarkers to maximize the productivity of clinical trials for neuropsychiatric symptoms.

Original languageEnglish (US)
Pages (from-to)98-102
Number of pages5
JournalThe journal of prevention of Alzheimer's disease
Volume5
Issue number2
DOIs
StatePublished - Jan 1 2018

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Keywords

  • agitation
  • Alzheimer’s disease
  • clinical trials
  • dementia
  • Neuropsychiatric symptoms
  • NPS outcome measures

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Sano, M., Soto, M., Carrillo, M., Cummings, J., Hendrix, S., Mintzer, J., Porsteinsson, A., Rosenberg, P., Schneider, L., Touchon, J., Aisen, P., Vellas, B., & Lyketsos, C. (2018). Identifying Better Outcome Measures to Improve Treatment of Agitation in Dementia: A Report from the EU/US/CTAD Task Force. The journal of prevention of Alzheimer's disease, 5(2), 98-102. https://doi.org/10.14283/jjpad.2018.15