Identifying a clinically meaningful threshold for change in uveitic macular edema evaluated by optical coherence tomography

Elizabeth Sugar, Douglas Jabs, Michael M. Altaweel, Sue Lightman, Nisha Acharya, Albert T. Vitale, Jennifer Thorne

Research output: Contribution to journalArticle


Purpose: To identify a clinically meaningful threshold for change in retinal thickness measured by optical coherence tomography for patients with uveitic macular edema using correlation with change in visual acuity. Design: Cross-sectional and longitudinal study. Methods: One hundred twenty-eight eyes (101 individuals) with macular edema enrolled in the Multicenter Uveitis Steroid Treatment (MUST) trial. At enrollment and after 6 months of follow-up, retinal thickness was measured at the central subfield with time-domain optical coherence tomography and visual acuity was measured with logarithmic (Early Treatment Diabetic Retinopathy Study) visual acuity charts. Participants were classified as having macular edema if the retinal thickness was 260 μm or more. Results: A threshold for change in retinal center subfield thickness of 20% balanced the percentage of false positives and false negatives for predicting more than a 10-letter change in visual acuity with a sensitivity of 77% and a specificity of 75%. The results were similar for more than 5-letter changes and for 15-letter or more changes. Those with a 20% or more reduction in retinal thickness had a mean 11.0-letter improvement (95% confidence interval, 7.7 to 14.3) as compared with a -0.4-letter change (95% confidence interval, -4.1 to 3.3) in visual acuity for those without a 20% reduction (P

Original languageEnglish (US)
JournalAmerican Journal of Ophthalmology
Issue number6
StatePublished - Dec 2011


ASJC Scopus subject areas

  • Ophthalmology

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