TY - JOUR
T1 - Identification, using sera from exposed animals, of putative viral antigens in livers of primates with callitrichid hepatitis
AU - Stephensen, Charles B.
AU - Montali, Richard J.
AU - Ramsay, Edward C.
AU - Holmes, Kathryn V.
PY - 1990
Y1 - 1990
N2 - Callitrichid hepatitis (CH) is an acute, frequently fatal viral hepatitis which affects members of the primate family Callitrichidae (R. J. Montali, E. C. Ramsay, C. B. Stephensen, M. Worley, J. A. Davis, and K. V. Holmes, J. Infect. Dis. 160:759-765, 1989; E. C. Ramsay, R. J. Montali, M. Worley, C. B. Stephensen, and K. V. Hlmes, J. Zoo Wildlife Med. 20:178-183). Outbreaks of the disease occur in zoos and animal parks. In this study, CH-specific antigens were identified in the livers of infected animals by iusing immune sera from primates with CH and CH-exposed asymptomatic animals. Three CH-specific antigens with apparent molecular masses of 34, 54, and 65 kDa were identified. A polyclonal antiserum was raised against the 54-kDa antigen. these antigens were not found in the livers of uninfected animals and may be viral proteins. Our results suggest that at least five of the six outbreaks of CH considered here were caused by the same virus or by an antigenically related virus.
AB - Callitrichid hepatitis (CH) is an acute, frequently fatal viral hepatitis which affects members of the primate family Callitrichidae (R. J. Montali, E. C. Ramsay, C. B. Stephensen, M. Worley, J. A. Davis, and K. V. Holmes, J. Infect. Dis. 160:759-765, 1989; E. C. Ramsay, R. J. Montali, M. Worley, C. B. Stephensen, and K. V. Hlmes, J. Zoo Wildlife Med. 20:178-183). Outbreaks of the disease occur in zoos and animal parks. In this study, CH-specific antigens were identified in the livers of infected animals by iusing immune sera from primates with CH and CH-exposed asymptomatic animals. Three CH-specific antigens with apparent molecular masses of 34, 54, and 65 kDa were identified. A polyclonal antiserum was raised against the 54-kDa antigen. these antigens were not found in the livers of uninfected animals and may be viral proteins. Our results suggest that at least five of the six outbreaks of CH considered here were caused by the same virus or by an antigenically related virus.
UR - http://www.scopus.com/inward/record.url?scp=0025226181&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025226181&partnerID=8YFLogxK
M3 - Article
C2 - 2123012
AN - SCOPUS:0025226181
SN - 0022-538X
VL - 64
SP - 6349
EP - 6354
JO - Journal of virology
JF - Journal of virology
IS - 12
ER -