Abstract
To rapidly discover clinically useful angiogenesis inhibitors, we created and screened a library of existing drugs for inhibition of endothelial cell proliferation. Mycophenolic acid (MPA), an immunosuppressive drug, was found to potently inhibit endothelial cell proliferation in vitro and block tumor-induced angiogenesis in vivo. Using RNA interference, we found that knockdown of one of the two known isoforms of inosine monophosphate dehydrogenase (IMPDH-1) is sufficient to cause endothelial cell cycle arrest.
Original language | English (US) |
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Pages (from-to) | 2677-2680 |
Number of pages | 4 |
Journal | Journal of medicinal chemistry |
Volume | 49 |
Issue number | 9 |
DOIs | |
State | Published - May 4 2006 |
ASJC Scopus subject areas
- Molecular Medicine
- Drug Discovery