Identification of transcription stop sites at the 5' and 3' ends of the murine adenosine deaminase gene

M. C. Maa, J. M. Chinsky, V. Ramamurthy, B. D. Martin, R. E. Kellems

Research output: Contribution to journalArticlepeer-review

Abstract

We report here the identification and nucleotide sequence of two transcription termination regions associated with the murine adenosine deaminase gene. One region is situated within or very near exon one and in mouse fibroblasts accounts for more than a 50-fold drop in the abundance of nascent transcripts. This termination region is believed to be involved in the regulation of adenosine deaminase gene transcription. The other termination region is located approximately 3.5 kilobases beyond the major polyadenylation site and defines the 3' boundary of the adenosine deaminase transcription unit.

Original languageEnglish (US)
Pages (from-to)12513-12519
Number of pages7
JournalJournal of Biological Chemistry
Volume265
Issue number21
StatePublished - 1990
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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