Identification of the Lymphatic Drainage Pattern of Esophageal Cancer with Near-Infrared Fluorescent Imaging

Francisco Schlottmann, Arianna Barbetta, Benedetto Mungo, Anne O. Lidor, Daniela Molena

Research output: Contribution to journalArticle

Abstract

Objective: Nodal status is one of the most important long-term prognostic factors for esophageal cancer. The aim of this study was to evaluate the ability of near-infrared (NIR) light fluorescent imaging to identify the lymphatic drainage pattern of esophageal cancer. Methods: Patients with distal esophageal cancer or esophagogastric junction cancer scheduled for esophagectomy were enrolled in this study. Before surgery, an endoscopy was performed with submucosal injection of 2 cc of indocyanine green (ICG) around the tumor. Real-time NIR images from the surgical field were obtained for each patient to visualize the lymphatic ICG drainage. Results: A total of nine patients were included in this study. Ivor Lewis esophagectomy was performed in all cases. ICG drainage was visualized to first drain along the left gastric nodes in eight patients (88.9%) and toward the diaphragmatic nodes in one patient (11.1%). The median number of resected nodes was 32. Three patients (33.3%) presented nodal involvement. All of them had positive nodes in the first nodal station identified with ICG. Conclusions: Evaluation of the lymphatic drainage pattern with real-time NIR light fluorescent technique is feasible. Distal and esophagogastric junction tumors showed to drain first in the left gastric nodes in most of the cases.

Original languageEnglish (US)
Pages (from-to)268-271
Number of pages4
JournalJournal of Laparoendoscopic and Advanced Surgical Techniques
Volume27
Issue number3
DOIs
StatePublished - Mar 1 2017

Fingerprint

Esophageal Neoplasms
Drainage
Indocyanine Green
Esophagogastric Junction
Esophagectomy
Stomach
Light
Neoplasms
Endoscopy
Injections

Keywords

  • esophageal cancer
  • lymphatic drainage
  • near-infrared imaging

ASJC Scopus subject areas

  • Surgery

Cite this

Identification of the Lymphatic Drainage Pattern of Esophageal Cancer with Near-Infrared Fluorescent Imaging. / Schlottmann, Francisco; Barbetta, Arianna; Mungo, Benedetto; Lidor, Anne O.; Molena, Daniela.

In: Journal of Laparoendoscopic and Advanced Surgical Techniques, Vol. 27, No. 3, 01.03.2017, p. 268-271.

Research output: Contribution to journalArticle

Schlottmann, Francisco ; Barbetta, Arianna ; Mungo, Benedetto ; Lidor, Anne O. ; Molena, Daniela. / Identification of the Lymphatic Drainage Pattern of Esophageal Cancer with Near-Infrared Fluorescent Imaging. In: Journal of Laparoendoscopic and Advanced Surgical Techniques. 2017 ; Vol. 27, No. 3. pp. 268-271.
@article{227f8dbc1d3f476a9fa5d13486a1f4e4,
title = "Identification of the Lymphatic Drainage Pattern of Esophageal Cancer with Near-Infrared Fluorescent Imaging",
abstract = "Objective: Nodal status is one of the most important long-term prognostic factors for esophageal cancer. The aim of this study was to evaluate the ability of near-infrared (NIR) light fluorescent imaging to identify the lymphatic drainage pattern of esophageal cancer. Methods: Patients with distal esophageal cancer or esophagogastric junction cancer scheduled for esophagectomy were enrolled in this study. Before surgery, an endoscopy was performed with submucosal injection of 2 cc of indocyanine green (ICG) around the tumor. Real-time NIR images from the surgical field were obtained for each patient to visualize the lymphatic ICG drainage. Results: A total of nine patients were included in this study. Ivor Lewis esophagectomy was performed in all cases. ICG drainage was visualized to first drain along the left gastric nodes in eight patients (88.9{\%}) and toward the diaphragmatic nodes in one patient (11.1{\%}). The median number of resected nodes was 32. Three patients (33.3{\%}) presented nodal involvement. All of them had positive nodes in the first nodal station identified with ICG. Conclusions: Evaluation of the lymphatic drainage pattern with real-time NIR light fluorescent technique is feasible. Distal and esophagogastric junction tumors showed to drain first in the left gastric nodes in most of the cases.",
keywords = "esophageal cancer, lymphatic drainage, near-infrared imaging",
author = "Francisco Schlottmann and Arianna Barbetta and Benedetto Mungo and Lidor, {Anne O.} and Daniela Molena",
year = "2017",
month = "3",
day = "1",
doi = "10.1089/lap.2016.0523",
language = "English (US)",
volume = "27",
pages = "268--271",
journal = "Journal of Laparoendoscopic and Advanced Surgical Techniques - Part A",
issn = "1092-6429",
publisher = "Mary Ann Liebert Inc.",
number = "3",

}

TY - JOUR

T1 - Identification of the Lymphatic Drainage Pattern of Esophageal Cancer with Near-Infrared Fluorescent Imaging

AU - Schlottmann, Francisco

AU - Barbetta, Arianna

AU - Mungo, Benedetto

AU - Lidor, Anne O.

AU - Molena, Daniela

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Objective: Nodal status is one of the most important long-term prognostic factors for esophageal cancer. The aim of this study was to evaluate the ability of near-infrared (NIR) light fluorescent imaging to identify the lymphatic drainage pattern of esophageal cancer. Methods: Patients with distal esophageal cancer or esophagogastric junction cancer scheduled for esophagectomy were enrolled in this study. Before surgery, an endoscopy was performed with submucosal injection of 2 cc of indocyanine green (ICG) around the tumor. Real-time NIR images from the surgical field were obtained for each patient to visualize the lymphatic ICG drainage. Results: A total of nine patients were included in this study. Ivor Lewis esophagectomy was performed in all cases. ICG drainage was visualized to first drain along the left gastric nodes in eight patients (88.9%) and toward the diaphragmatic nodes in one patient (11.1%). The median number of resected nodes was 32. Three patients (33.3%) presented nodal involvement. All of them had positive nodes in the first nodal station identified with ICG. Conclusions: Evaluation of the lymphatic drainage pattern with real-time NIR light fluorescent technique is feasible. Distal and esophagogastric junction tumors showed to drain first in the left gastric nodes in most of the cases.

AB - Objective: Nodal status is one of the most important long-term prognostic factors for esophageal cancer. The aim of this study was to evaluate the ability of near-infrared (NIR) light fluorescent imaging to identify the lymphatic drainage pattern of esophageal cancer. Methods: Patients with distal esophageal cancer or esophagogastric junction cancer scheduled for esophagectomy were enrolled in this study. Before surgery, an endoscopy was performed with submucosal injection of 2 cc of indocyanine green (ICG) around the tumor. Real-time NIR images from the surgical field were obtained for each patient to visualize the lymphatic ICG drainage. Results: A total of nine patients were included in this study. Ivor Lewis esophagectomy was performed in all cases. ICG drainage was visualized to first drain along the left gastric nodes in eight patients (88.9%) and toward the diaphragmatic nodes in one patient (11.1%). The median number of resected nodes was 32. Three patients (33.3%) presented nodal involvement. All of them had positive nodes in the first nodal station identified with ICG. Conclusions: Evaluation of the lymphatic drainage pattern with real-time NIR light fluorescent technique is feasible. Distal and esophagogastric junction tumors showed to drain first in the left gastric nodes in most of the cases.

KW - esophageal cancer

KW - lymphatic drainage

KW - near-infrared imaging

UR - http://www.scopus.com/inward/record.url?scp=85015359196&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85015359196&partnerID=8YFLogxK

U2 - 10.1089/lap.2016.0523

DO - 10.1089/lap.2016.0523

M3 - Article

C2 - 27992300

AN - SCOPUS:85015359196

VL - 27

SP - 268

EP - 271

JO - Journal of Laparoendoscopic and Advanced Surgical Techniques - Part A

JF - Journal of Laparoendoscopic and Advanced Surgical Techniques - Part A

SN - 1092-6429

IS - 3

ER -