Identification of susceptibility genes loci associated with type 2 diabetes

Lifei Liu, Jingjing Lei, Haiyun Liu, Qinjie Zou, Yuhua Sun, Yancheng Xu, Huimin Bi, Fengjiao Deng, Xueling Shao, Siyang Liu

Research output: Contribution to journalArticlepeer-review

Abstract

In this study, we selected 10 susceptible SNPs loci to investigate their contribution to susceptibility to type 2 diabetes in Han Chinese among Hubei population. We genotyped SNPs rs5219, rs1801282, rs1470579, rs1111875, rs1081661, rs7754840, rs4506565, rs13266634, rs4402960, and rs5643981 by using the method of polymerase chain reaction-ligase detection reaction (PCR-LDR). In a case-control study, we have genotyped the 10 candidate susceptibility SNP loci, and here, we reported that the SNP rs5219 in KCNJ11 was strongly associated with type 2 diabetes in Han Chinese in Hubei China. There were significant differences in the TT genotype frequency (OR=1.6, 95%CI 1.1-2.3, p=0.01) and T allele frequency (OR=1.3, 95%CI 1.1-1.6, p=0.03) of SNP rs5219 between cases and controls. The other nine SNP loci did not show significant association with type 2 diabetes in Han Chinese in Hubei. The result suggests that KCNJ11 gene is a susceptibility gene of type 2 diabetes among this population.

Original languageEnglish (US)
Pages (from-to)171-175
Number of pages5
JournalWuhan University Journal of Natural Sciences
Volume15
Issue number2
DOIs
StatePublished - Apr 2010
Externally publishedYes

Keywords

  • Polymerase chain reaction-ligase detection reaction (PCR-LDR)
  • Single nucleotide polymorphism
  • Susceptibility gene
  • Type 2 diabetes

ASJC Scopus subject areas

  • General

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