Identification of Spin Diffusion Pathways in Isotopically Labeled Biomolecules

Thomas R. Eykyn, Dominique Früh, Geoffrey Bodenhausen

Research output: Contribution to journalEditorialpeer-review

Abstract

One-dimensional NOE experiments applicable to labeled macromolecules are presented which allow the manipulation of specific spin diffusion pathways and thus unambiguously identify clandestine spins through which the direct NOE is mediated. A treatment of spin diffusion using average Liouvillian theory is shown to describe adequately these phenomena. Experiments are carried out on an 15 N-labeled sample of human ubiquitin.

Original languageEnglish (US)
Pages (from-to)330-333
Number of pages4
JournalJournal of Magnetic Resonance
Volume138
Issue number2
DOIs
StatePublished - Jun 1999
Externally publishedYes

Keywords

  • Average Liouvillian theory
  • Protein NMR
  • Selective NOE
  • Spin diffusion

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Nuclear and High Energy Physics
  • Condensed Matter Physics

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