Identification of seizure pathways by spectral analysis of EEG

Yien Che Tsai, David L. Sherman, Lisa Ann Rossell, Marek A. Mirski, Nitish V. Thakor

Research output: Contribution to journalConference article


We hypothesize that anterior thalamus, a subcortical center important for seizure expression, exhibits high signal coherence with cortex during a clonic seizure expression. In addition, the partial coherence would not vanish when the effects of an inert center are removed by a partial regression analysis. Generalized seizures are induced in rats (n = 6) using pentylentetrazol (PTZ) and EEG recorded from cortical and subcortical sites. Statistical analysis of coherence and partial coherence indicates that anterior thalamic and cortical EEG are highly coherent during a clonic seizure expression. Coherence analysis can therefore provide details of the pathway for the spread of seizure activities between subcortical and cortical brain.

Original languageEnglish (US)
Pages (from-to)897-898
Number of pages2
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Issue number2
StatePublished - Dec 1 1995
EventProceedings of the 1995 IEEE Engineering in Medicine and Biology 17th Annual Conference and 21st Canadian Medical and Biological Engineering Conference. Part 2 (of 2) - Montreal, Can
Duration: Sep 20 1995Sep 23 1995

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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