Identification of region specific genes by chromosome microdissection

Paul S. Meltzer, Xin Yuan Guan, Yan An Su, Edgardo Gracia, Jeffrey M. Trent

Research output: Contribution to journalArticlepeer-review


Chromosome microdissection is an extremely useful molecular cytogenetic tool for the characterization of chromosomal abnormalities in tumor cells. Although it has been used primarily in conjunction with fluorescence in situ hybridization (FISH), microdissection has also been useful for molecular analysis via microclone library construction. Recently, microdissection has been applied to the isolation of region specific cDNAs with sufficient success that gene discovery can now be added to the list of applications of this versatile molecular cytogenetic technique.

Original languageEnglish (US)
Pages (from-to)29-32
Number of pages4
JournalCancer Genetics and Cytogenetics
Issue number1
StatePublished - Jan 1997
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research


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