Identification of Receptor Populations Mediating the Satiating Actions of Brain and Gut Peptides

The chapter provides a critical discussion of techniques for measuring peptide receptor function and demonstrating the successful use of these techniques to identify and investigate receptors for cholecystokinin and bombesin-like peptides. The chapter shows the satiating effect of cholecystokinin and bombesin-like peptides which has been successfully pursued to the level of cellular function. It focuses on the identification of discrete receptor subpopulations whose pharmacological specificity and location make them leading candidates for mediating the satiety actions of CCK and BN-like peptides.