Identification of ras oncogene mutations in the stool of patients with curable colorectal tumors

David Sidransky, Takashi Tokino, Stanley R. Hamilton, Kenneth W. Kinzler, Bernard Levin, Philip Frost, Bert Vogelstein

Research output: Contribution to journalArticle

Abstract

Colorectal (CR) tumors are usually curable if detected before metastasis. Because genetic alterations are associated with the development of these tumors, mutant genes may be found in the stool of individuals with CR neoplasms. The stools of nine patients whose tumors contained mutations of K-ras were analyzed. In eight of the nine cases, the ras mutations were detectable in DNA purified from the stool. These patients included those with benign and malignant neoplasms from proximal and distal colonic epithelium. Thus, colorectal tumors can be detected by a noninvasive method based on the molecular pathogenesis of the disease.

Original languageEnglish (US)
Pages (from-to)102-105
Number of pages4
JournalScience
Volume256
Issue number5053
DOIs
StatePublished - Jan 1 1992

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