Identification of plasmodium GAPDH epitopes for generation of antibodies that inhibit malaria infection

Sung Jae Cha, Kyle Jarrod McLean, Marcelo Jacobs-Lorena

Research output: Contribution to journalArticlepeer-review

Abstract

Plasmodium sporozoite liver infection is an essential step for parasite development in its mammalian host. Previously, we used a phage display library to identify mimotope peptides that bind to Kupffer cells and competitively inhibit sporozoite–Kupffer cell interaction. These peptides led to the identification of a Kupffer cell receptor—CD68—and a Plasmodium sporozoite ligand—GAPDH—that are required for sporozoite traversal of Kupffer cells and subsequent infection of hepatocytes. Here, we report that the C-terminal end of Plasmodium GAPDH interacts with the Kupffer CD68 receptor, and identify two epitopes within this region as candidate antigens for the development of antibodies that inhibit Plasmodium infection.

Original languageEnglish (US)
Article numbere201800111
JournalLife science alliance
Volume1
Issue number5
DOIs
StatePublished - 2018

ASJC Scopus subject areas

  • Ecology
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Plant Science
  • Health, Toxicology and Mutagenesis

Fingerprint Dive into the research topics of 'Identification of plasmodium GAPDH epitopes for generation of antibodies that inhibit malaria infection'. Together they form a unique fingerprint.

Cite this