TY - JOUR
T1 - Identification of pathogens from the upper respiratory tract of adult emergency department patients at high risk for influenza complications in a pre-Sars-CoV-2 environment
AU - for the Emergency Department National Network Influenza Investigators
AU - Hardick, Justin
AU - Shaw-Saliba, Kathryn
AU - McBryde, Breana
AU - Gaydos, Charlotte A.
AU - Hsieh, Yu Hsiang
AU - Lovecchio, Frank
AU - Steele, Mark
AU - Talan, David
AU - Rothman, Richard E.
N1 - Funding Information:
This work was supported by a cooperative agreement between Johns Hopkins University (JHU) and the US Department of Health and Human Services Biomedical Advanced Research and Development Authority (BARDA; grant number IDSEP150026-01-00 ). Work was also supported in part by the National Institute of Allergy and Infectious Diseases Contract HHSN272201400007C awarded to the Johns Hopkins Center for Influenza Research and Surveillance (JHCEIRS) at the Johns Hopkins University. Any opinions, finding, conclusions or recommendations expressed in this publication are those of the author(s) and do not represent the policy or position of NIAID or NIH.
Funding Information:
This work was supported by a cooperative agreement between Johns Hopkins University (JHU) and the US Department of Health and Human Services Biomedical Advanced Research and Development Authority (BARDA; grant number IDSEP150026-01-00). Work was also supported in part by the National Institute of Allergy and Infectious Diseases Contract HHSN272201400007C awarded to the Johns Hopkins Center for Influenza Research and Surveillance (JHCEIRS) at the Johns Hopkins University. Any opinions, finding, conclusions or recommendations expressed in this publication are those of the author(s) and do not represent the policy or position of NIAID or NIH.
Funding Information:
Justin Hardick received grants from BARDA and NIAID (BARDA (IDSEP150026-01-00), NIAID (Contract HHSN272201400007C)).
Publisher Copyright:
© 2021
PY - 2021/6
Y1 - 2021/6
N2 - The emergence of SARS-CoV-2 and subsequent COVID-19 pandemic highlights the morbidity and potential disease severity caused by respiratory viruses. To elucidate pathogen prevalence, etiology of coinfections and URIs from symptomatic adult Emergency department patients in a pre-SARS-CoV-2 environment, we evaluated specimens from four geographically diverse Emergency departments in the United States from 2013-2014 utilizing ePlex RP RUO cartridges (Genmark Diagnostics). The overall positivity was 30.1% (241/799), with 6.6% (16/241) coinfections. Noninfluenza pathogens from most to least common were rhinovirus/enterovirus, coronavirus, human metapneumovirus and RSV, respectively. Broad differences in disease prevalence and pathogen distributions were observed across geographic regions; the site with the highest detection rate (for both mono and coinfections) demonstrated the greatest pathogen diversity. A variety of respiratory pathogens and geographic variations in disease prevalence and copathogen type were observed. Further research is required to evaluate the clinical relevance of these findings, especially considering the SARS-CoV-2 pandemic and related questions regarding SARS-CoV-2 disease severity and the presence of co-infections.
AB - The emergence of SARS-CoV-2 and subsequent COVID-19 pandemic highlights the morbidity and potential disease severity caused by respiratory viruses. To elucidate pathogen prevalence, etiology of coinfections and URIs from symptomatic adult Emergency department patients in a pre-SARS-CoV-2 environment, we evaluated specimens from four geographically diverse Emergency departments in the United States from 2013-2014 utilizing ePlex RP RUO cartridges (Genmark Diagnostics). The overall positivity was 30.1% (241/799), with 6.6% (16/241) coinfections. Noninfluenza pathogens from most to least common were rhinovirus/enterovirus, coronavirus, human metapneumovirus and RSV, respectively. Broad differences in disease prevalence and pathogen distributions were observed across geographic regions; the site with the highest detection rate (for both mono and coinfections) demonstrated the greatest pathogen diversity. A variety of respiratory pathogens and geographic variations in disease prevalence and copathogen type were observed. Further research is required to evaluate the clinical relevance of these findings, especially considering the SARS-CoV-2 pandemic and related questions regarding SARS-CoV-2 disease severity and the presence of co-infections.
KW - Coinfections
KW - Emergency department
KW - Influenza
KW - Multiplex diagnostics
KW - Respiratory infections
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U2 - 10.1016/j.diagmicrobio.2021.115352
DO - 10.1016/j.diagmicrobio.2021.115352
M3 - Article
C2 - 33639376
AN - SCOPUS:85101380587
SN - 0732-8893
VL - 100
JO - Diagnostic Microbiology and Infectious Disease
JF - Diagnostic Microbiology and Infectious Disease
IS - 2
M1 - 115352
ER -