Identification of Nuclear Matrix Proteins in the Cancer and Normal Rat Prostate

Robert H. Getzenberg, Kenneth J. Pienta, Edwin Y.W. Huang, Donald S. Coffey

Research output: Contribution to journalArticle

Abstract

The nuclear matrix is the structural component of the nucleus that determines nuclear morphology and organizes the DNA in a threedimensional fashion that is tissue specific. Previously, some of the nuclear matrix proteins have been reported to be both tissue and cell type specific and are altered with the state of differentiation and transformation. This study demonstrates that the nuclear matrix is specific for the individual lobes of the normal rat prostate and that the nuclear matrix undergoes changes in protein composition in the Dunning prostate cancer tissue. Additionally, in the Dunning rat prostate adenocarcinoma cell lines, there is a range of tumor phenotypes and the nuclear matrix varies in composition in each tumor cell type. These differences in the nuclear matrix proteins are associated with quantitative changes in nuclear morphology that form the pleiomorphic state of the cancer nucleus.

Original languageEnglish (US)
Pages (from-to)6514-6520
Number of pages7
JournalCancer Research
Volume51
Issue number24
StatePublished - Dec 1991

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Getzenberg, R. H., Pienta, K. J., Huang, E. Y. W., & Coffey, D. S. (1991). Identification of Nuclear Matrix Proteins in the Cancer and Normal Rat Prostate. Cancer Research, 51(24), 6514-6520.