Identification of nuclear matrix proteins in the cancer and normal rat prostate

Robert H. Getzenberg, Kenneth Pienta, Edwin Y W Huang, Donald S. Coffey

Research output: Contribution to journalArticle

Abstract

The nuclear matrix is the structural component of the nucleus that determines nuclear morphology and organizes the DNA in a three-dimensional fashion that is tissue specific. Previously, some of the nuclear matrix proteins have been reported to be both tissue and cell type specific and are altered with the state of differentiation and transformation. This study demonstrates that the nuclear matrix is specific for the individual lobes of the normal rat prostate and that the nuclear matrix undergoes changes in protein composition in the Dunning prostate cancer tissue. Additionally, in the Dunning rat prostate adenocarcinoma cell lines, there is a range of tumor phenotypes and the nuclear matrix varies in composition in each tumor cell type. These differences in the nuclear matrix proteins are associated with quantitative changes in nuclear morphology that form the pleiomorphic state of the cancer nucleus.

Original languageEnglish (US)
Pages (from-to)6514-6520
Number of pages7
JournalCancer Research
Volume51
Issue number24
StatePublished - Dec 15 1991

Fingerprint

Nuclear Matrix-Associated Proteins
Nuclear Matrix
Prostate
Neoplasms
Prostatic Neoplasms
Adenocarcinoma
Phenotype
Cell Line
DNA
Proteins

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Getzenberg, R. H., Pienta, K., Huang, E. Y. W., & Coffey, D. S. (1991). Identification of nuclear matrix proteins in the cancer and normal rat prostate. Cancer Research, 51(24), 6514-6520.

Identification of nuclear matrix proteins in the cancer and normal rat prostate. / Getzenberg, Robert H.; Pienta, Kenneth; Huang, Edwin Y W; Coffey, Donald S.

In: Cancer Research, Vol. 51, No. 24, 15.12.1991, p. 6514-6520.

Research output: Contribution to journalArticle

Getzenberg, RH, Pienta, K, Huang, EYW & Coffey, DS 1991, 'Identification of nuclear matrix proteins in the cancer and normal rat prostate', Cancer Research, vol. 51, no. 24, pp. 6514-6520.
Getzenberg RH, Pienta K, Huang EYW, Coffey DS. Identification of nuclear matrix proteins in the cancer and normal rat prostate. Cancer Research. 1991 Dec 15;51(24):6514-6520.
Getzenberg, Robert H. ; Pienta, Kenneth ; Huang, Edwin Y W ; Coffey, Donald S. / Identification of nuclear matrix proteins in the cancer and normal rat prostate. In: Cancer Research. 1991 ; Vol. 51, No. 24. pp. 6514-6520.
@article{a9955763f4ba488fbd4bd4a31216a1eb,
title = "Identification of nuclear matrix proteins in the cancer and normal rat prostate",
abstract = "The nuclear matrix is the structural component of the nucleus that determines nuclear morphology and organizes the DNA in a three-dimensional fashion that is tissue specific. Previously, some of the nuclear matrix proteins have been reported to be both tissue and cell type specific and are altered with the state of differentiation and transformation. This study demonstrates that the nuclear matrix is specific for the individual lobes of the normal rat prostate and that the nuclear matrix undergoes changes in protein composition in the Dunning prostate cancer tissue. Additionally, in the Dunning rat prostate adenocarcinoma cell lines, there is a range of tumor phenotypes and the nuclear matrix varies in composition in each tumor cell type. These differences in the nuclear matrix proteins are associated with quantitative changes in nuclear morphology that form the pleiomorphic state of the cancer nucleus.",
author = "Getzenberg, {Robert H.} and Kenneth Pienta and Huang, {Edwin Y W} and Coffey, {Donald S.}",
year = "1991",
month = "12",
day = "15",
language = "English (US)",
volume = "51",
pages = "6514--6520",
journal = "Journal of Cancer Research",
issn = "0099-7013",
publisher = "American Association for Cancer Research Inc.",
number = "24",

}

TY - JOUR

T1 - Identification of nuclear matrix proteins in the cancer and normal rat prostate

AU - Getzenberg, Robert H.

AU - Pienta, Kenneth

AU - Huang, Edwin Y W

AU - Coffey, Donald S.

PY - 1991/12/15

Y1 - 1991/12/15

N2 - The nuclear matrix is the structural component of the nucleus that determines nuclear morphology and organizes the DNA in a three-dimensional fashion that is tissue specific. Previously, some of the nuclear matrix proteins have been reported to be both tissue and cell type specific and are altered with the state of differentiation and transformation. This study demonstrates that the nuclear matrix is specific for the individual lobes of the normal rat prostate and that the nuclear matrix undergoes changes in protein composition in the Dunning prostate cancer tissue. Additionally, in the Dunning rat prostate adenocarcinoma cell lines, there is a range of tumor phenotypes and the nuclear matrix varies in composition in each tumor cell type. These differences in the nuclear matrix proteins are associated with quantitative changes in nuclear morphology that form the pleiomorphic state of the cancer nucleus.

AB - The nuclear matrix is the structural component of the nucleus that determines nuclear morphology and organizes the DNA in a three-dimensional fashion that is tissue specific. Previously, some of the nuclear matrix proteins have been reported to be both tissue and cell type specific and are altered with the state of differentiation and transformation. This study demonstrates that the nuclear matrix is specific for the individual lobes of the normal rat prostate and that the nuclear matrix undergoes changes in protein composition in the Dunning prostate cancer tissue. Additionally, in the Dunning rat prostate adenocarcinoma cell lines, there is a range of tumor phenotypes and the nuclear matrix varies in composition in each tumor cell type. These differences in the nuclear matrix proteins are associated with quantitative changes in nuclear morphology that form the pleiomorphic state of the cancer nucleus.

UR - http://www.scopus.com/inward/record.url?scp=0026317357&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026317357&partnerID=8YFLogxK

M3 - Article

C2 - 1742724

AN - SCOPUS:0026317357

VL - 51

SP - 6514

EP - 6520

JO - Journal of Cancer Research

JF - Journal of Cancer Research

SN - 0099-7013

IS - 24

ER -