Identification of novel short peptides derived from the α4, α5, and α6 fibrils of type IV collagen with anti-angiogenic properties

Emmanouil D. Karagiannis, Aleksander S. Popel

Research output: Contribution to journalArticle

Abstract

Angiogenesis, or neovascularization, is tightly controlled by positive and negative regulators, many of which reside in the extracellular matrix. We have now identified eight novel 19- to 20-residue peptides derived from the α4, α5, and α6 fibrils of type IV collagen, which we have designated tetrastatins, pentastatins, and hexastatins, respectively. We have shown that these endogenous peptides suppress the proliferation and migration of HUVECs in vitro. By performing clustering analyses of the sequences using sequence similarity criteria and of the experimental results using a hierarchical algorithm, we report that the clusters identified by the experimental results coincide with the sequence-based clusters, indicating a tight relationship between peptide sequence and anti-angiogenic potency. These peptides may have potential as anti-angiogenic therapeutic agents.

Original languageEnglish (US)
Pages (from-to)434-439
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume354
Issue number2
DOIs
StatePublished - Mar 9 2007

Keywords

  • Angiogenesis
  • Endogenous
  • Endothelial cell
  • Hexastatin
  • Inhibitor
  • Pentastatin
  • Tetrastatin

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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