Identification of novel bladder sensory GPCRs

Tilmira A. Smith, Brittni N. Moore, Andres Matoso, Dan E. Berkowitz, Jennifer J. DeBerry, Jennifer L. Pluznick

Research output: Contribution to journalArticlepeer-review

Abstract

Sensory GPCRs such as olfactory receptors (ORs), taste receptors (TRs), and opsins (OPNs) are now known to play important physiological roles beyond their traditional sensory organs. Here, we systematically investigate the expression of sensory GPCRs in the urinary bladder for the first time. We find that the murine bladder expresses 16 ORs, 7 TRs, and 3 OPNs. We additionally explore the ectopic expression of these GPCRs in tissues beyond the bladder, as well as the localization within the bladder. In future work, understanding the functional roles of these bladder sensory GPCRs may shed light on novel mechanisms which modulate bladder function in health and disease.

Original languageEnglish (US)
Article numbere14840
JournalPhysiological Reports
Volume9
Issue number8
DOIs
StatePublished - Apr 2021
Externally publishedYes

Keywords

  • ectopic
  • olfactory receptor
  • opsin
  • taste receptor

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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