Identification of new CRF51-01B in Singapore using full genome analysis of three HIV type 1 isolates

Oon Tek Ng, Lindsay M. Eyzaguirre, Jean K. Carr, Kuan Kiat Chew, Li Lin, Arlene Chua, Yee Sin Leo, Andrew D. Redd, Thomas C. Quinn, Oliver Laeyendecker

Research output: Contribution to journalArticlepeer-review

Abstract

A recent HIV-1 molecular epidemiology survey in Singapore identified a novel CRF01-AE/B recombinant form, which accounted for 13 (11.9%) of 109 patient samples. Peripheral blood mononuclear cell DNA from three of these 13 patients was used to generate near full-length sequences to characterize the novel CRF01-AE/B recombinant form. The three isolates had a recombinant structure composed of CRF01-AE and subtype B, and shared identical breakpoints. As the three patients were not epidemiologically linked, this recombinant form has been designated CRF51-01B. Identification of the novel recombinant forms indicates ongoing active HIV-1 transmission in Singapore.

Original languageEnglish (US)
Pages (from-to)527-530
Number of pages4
JournalAIDS research and human retroviruses
Volume28
Issue number5
DOIs
StatePublished - May 1 2012

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

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