Identification of mycobacterium genavense in a diana monkey (cercopithecus diana) by polymerase chain reaction and high-performance liquid chromatography

Kathleen M. Kelly, Allison N. Wack, Dan Bradway, Brian W. Simons, Ellen Bronson, Gerard Osterhout, Nicole M Parrish, Richard J. Montali

Research output: Contribution to journalArticle


A 25-yr-old Diana monkey (Cercopithecus diana) with a 1.5-yr history of chronic colitis and diarrhea was found to have disseminated granulomatous disease with intralesional acid fast bacilli. Bacilli were identified as Mycobacterium genavense by polymerase chain reaction, sequencing of the 16S-23S ribosomal RNA intergenic spacer (ITS) gene, and mycolic acid analysis by high-performance liquid chromatography. Mycobacterium genavense is a common cause of mycobacteriosis in free-ranging and captive birds. In addition, recognition of opportunistic infection in human immunodeficiency virus-positive patients is increasing. Disease manifestations of M. genavense are similar to Mycobacterium avium complex (MAC) and include fever, wasting, and diarrhea with disseminated disease. Similar clinical signs and lesions were observed in this monkey. Mycobacterium genavense should be considered as a differential for disseminated mycobacterial disease in nonhuman primates as this agent can mimic MAC and related mycobacteria.

Original languageEnglish (US)
Pages (from-to)339-344
Number of pages6
JournalJournal of Zoo and Wildlife Medicine
Issue number2
Publication statusPublished - Jun 1 2015



  • Diana monkey
  • mycobacteriosis
  • Mycobacterium genavense
  • mycolic acid
  • nontuberculous
  • polymerase chain reaction

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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