Identification of mononuclear cells in CSF of patients with HIV infection

Research output: Contribution to journalArticle

Abstract

Using immunocytochemical methods, CSF lymphocyte subpopulations were examined in different neurologic disorders associated with human immunodeficiency virus (HIV) infection. CSF pleocytosis was observed in asymptomatic neurologically normal subjects, in patients with aseptic meningitis, and those with inflammatory demyelinating neuropathies, but infrequently in subjects with AIDS dementia complex. The distribution of CSF lymphocyte subpopulations in HIV-infected patients differed from control subjecta showing decreases in percentages of T helper (CD4) cells and increases in T suppressor (CD8) cells. Peripheral blood and CSF CD4: CD8 ratios were inverted in all of the neurologic disorders studied. In all disorders, the changes in CSF composition of mononuclear cells paralleled alterations in peripheral blood and in patients with AIDS dementia complex, there was a relationship between the severity of dementia and blood and CSF CD4 lymphocyte proportions.

Original languageEnglish (US)
Pages (from-to)66-70
Number of pages5
JournalNeurology
Volume39
Issue number1
StatePublished - 1989

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Virus Diseases
AIDS Dementia Complex
Lymphocyte Subsets
HIV
Nervous System Diseases
Aseptic Meningitis
CD4-CD8 Ratio
Leukocytosis
Helper-Inducer T-Lymphocytes
Dementia
Lymphocytes
AIDS/HIV
Cells
Blood

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Identification of mononuclear cells in CSF of patients with HIV infection. / McArthur, Justin Charles; Sipos, E.; Cornblath, David; Welch, D.; Chupp, M.; Griffin, Diane; Johnson, Richard.

In: Neurology, Vol. 39, No. 1, 1989, p. 66-70.

Research output: Contribution to journalArticle

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