Abstract
It has been shown that human monocytes express monocyte chemoattractant protein-1 (MCP-1), an inflammatory factor, in response to non-fibrillar β- amyloid protein. Reactive microglia and inflammatory factors were reported to be present in β-amyloid deposits (senile plaques) in Alzheimer's disease, suggesting the presence of MCP-1 in senile plaques. To address this issue, we examined MCP-1-immunoreactivity in senile plaques using a mouse monoclonal anti-MCP-1 antibody. Monocyte chemoattractant protein-1 was found immunohistochemically in mature senile plaques and reactive microglia but not in immature senile plaques of brain tissues from five patients with Alzheimer's disease. These findings suggest that MCP-1-related inflammatory events induced by reactive microglia contribute to the maturation of senile plaques.
Original language | English (US) |
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Pages (from-to) | 135-138 |
Number of pages | 4 |
Journal | Psychiatry and Clinical Neurosciences |
Volume | 51 |
Issue number | 3 |
DOIs | |
State | Published - 1997 |
Externally published | Yes |
Keywords
- Alzheimer's disease
- Inflammation
- Microglias
- Monocyte chemoattractant protein-1
- Senile plaques
ASJC Scopus subject areas
- General Neuroscience
- Neurology
- Clinical Neurology
- Psychiatry and Mental health