Identification of monocyte chemoattractant protein-1 in senile plaques and reactive microglia of Alzheimer's disease

Koko Ishizuka, Takemi Kimura, Ruriko Igata-Yi, Shoichi Katsuragi, Junichi Takamatsu, Taihei Miyakawa

Research output: Contribution to journalArticle

Abstract

It has been shown that human monocytes express monocyte chemoattractant protein-1 (MCP-1), an inflammatory factor, in response to non-fibrillar β- amyloid protein. Reactive microglia and inflammatory factors were reported to be present in β-amyloid deposits (senile plaques) in Alzheimer's disease, suggesting the presence of MCP-1 in senile plaques. To address this issue, we examined MCP-1-immunoreactivity in senile plaques using a mouse monoclonal anti-MCP-1 antibody. Monocyte chemoattractant protein-1 was found immunohistochemically in mature senile plaques and reactive microglia but not in immature senile plaques of brain tissues from five patients with Alzheimer's disease. These findings suggest that MCP-1-related inflammatory events induced by reactive microglia contribute to the maturation of senile plaques.

Original languageEnglish (US)
Pages (from-to)135-138
Number of pages4
JournalPsychiatry and Clinical Neurosciences
Volume51
Issue number3
DOIs
StatePublished - Jan 1 1997
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Inflammation
  • Microglias
  • Monocyte chemoattractant protein-1
  • Senile plaques

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health

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