Identification of loci associated with schizophrenia by genome-wide association and follow-up

Michael C. O'Donovan; Nicholas Craddock; Nadine Norton; Hywel Williams; Timothy Peirce; Valentina Moskvina; Ivan Nikolov; Marian Hamshere; Liam Carroll; Lyudmila Georgieva; Sarah Dwyer; Peter Holmans; Jonathan L. Marchini; Chris C A Spencer; Bryan Howie; Hin Tak Leung; Annette M. Hartmann; Hans Jürgen Möller; Derek W. Morris; YongYong Shi; GuoYin Feng; Per Hoffmann; Peter Propping; Catalina Vasilescu; Wolfgang Maier; Marcella Rietschel; Stanley Zammit; Johannes Schumacher; Emma M. Quinn; Thomas G. Schulze; Nigel M. Williams; Ina Giegling; Nakao Iwata; Masashi Ikeda; Ariel Darvasi; Sagiv Shifman; Lin He; Jubao Duan; Alan R. Sanders; Douglas F. Levinson; Pablo V. Gejman; Nancy G. Buccola; Bryan J. Mowry; Robert Freedman; Farooq Amin; Donald W. Black; Jeremy M. Silverman; William F. Byerley; C. Robert Cloninger; Sven Cichon; Markus M. Nöthen; Michael Gill; Aiden Corvin; Dan Rujescu; George Kirov; Michael J. Owen

doi:10.1038/ng.201

Identification of loci associated with schizophrenia by genome-wide association and follow-up

Michael C. O'Donovan, Nicholas Craddock, Nadine Norton, Hywel Williams, Timothy Peirce, Valentina Moskvina, Ivan Nikolov, Marian Hamshere, Liam Carroll, Lyudmila Georgieva, Sarah Dwyer, Peter Holmans, Jonathan L. Marchini, Chris C A Spencer, Bryan Howie, Hin Tak Leung, Annette M. Hartmann, Hans Jürgen Möller, Derek W. Morris, YongYong ShiGuoYin Feng, Per Hoffmann, Peter Propping, Catalina Vasilescu, Wolfgang Maier, Marcella Rietschel, Stanley Zammit, Johannes Schumacher, Emma M. Quinn, Thomas G. Schulze, Nigel M. Williams, Ina Giegling, Nakao Iwata, Masashi Ikeda, Ariel Darvasi, Sagiv Shifman, Lin He, Jubao Duan, Alan R. Sanders, Douglas F. Levinson, Pablo V. Gejman, Nancy G. Buccola, Bryan J. Mowry, Robert Freedman, Farooq Amin, Donald W. Black, Jeremy M. Silverman, William F. Byerley, C. Robert Cloninger, Sven Cichon, Markus M. Nöthen, Michael Gill, Aiden Corvin, Dan Rujescu, George Kirov, Michael J. Owen

Research output: Contribution to journal › Article › peer-review

854 Scopus citations

Abstract

We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P <10^-5 in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong independent support (P <5 × 10^-4), and the overall pattern of replication was unlikely to occur by chance (P = 9 × 10^-8). Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 × 10^-7) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 × 10^-9).

Original language	English (US)
Pages (from-to)	1053-1055
Number of pages	3
Journal	Nature Genetics
Volume	40
Issue number	9
DOIs	https://doi.org/10.1038/ng.201
State	Published - Sep 2008
Externally published	Yes

ASJC Scopus subject areas

Genetics(clinical)
Genetics

Access to Document

10.1038/ng.201

Cite this

O'Donovan, M. C., Craddock, N., Norton, N., Williams, H., Peirce, T., Moskvina, V., Nikolov, I., Hamshere, M., Carroll, L., Georgieva, L., Dwyer, S., Holmans, P., Marchini, J. L., Spencer, C. C. A., Howie, B., Leung, H. T., Hartmann, A. M., Möller, H. J., Morris, D. W., ... Owen, M. J. (2008). Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nature Genetics, 40(9), 1053-1055. https://doi.org/10.1038/ng.201

O'Donovan, MC, Craddock, N, Norton, N, Williams, H, Peirce, T, Moskvina, V, Nikolov, I, Hamshere, M, Carroll, L, Georgieva, L, Dwyer, S, Holmans, P, Marchini, JL, Spencer, CCA, Howie, B, Leung, HT, Hartmann, AM, Möller, HJ, Morris, DW, Shi, Y, Feng, G, Hoffmann, P, Propping, P, Vasilescu, C, Maier, W, Rietschel, M, Zammit, S, Schumacher, J, Quinn, EM, Schulze, TG, Williams, NM, Giegling, I, Iwata, N, Ikeda, M, Darvasi, A, Shifman, S, He, L, Duan, J, Sanders, AR, Levinson, DF, Gejman, PV, Buccola, NG, Mowry, BJ, Freedman, R, Amin, F, Black, DW, Silverman, JM, Byerley, WF, Cloninger, CR, Cichon, S, Nöthen, MM, Gill, M, Corvin, A, Rujescu, D, Kirov, G & Owen, MJ 2008, 'Identification of loci associated with schizophrenia by genome-wide association and follow-up', Nature Genetics, vol. 40, no. 9, pp. 1053-1055. https://doi.org/10.1038/ng.201

@article{47de6b7af073459cb2e745b2f072c1af,

title = "Identification of loci associated with schizophrenia by genome-wide association and follow-up",

abstract = "We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P <10-5 in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong independent support (P <5 × 10-4), and the overall pattern of replication was unlikely to occur by chance (P = 9 × 10-8). Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 × 10-7) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 × 10-9).",

author = "O'Donovan, {Michael C.} and Nicholas Craddock and Nadine Norton and Hywel Williams and Timothy Peirce and Valentina Moskvina and Ivan Nikolov and Marian Hamshere and Liam Carroll and Lyudmila Georgieva and Sarah Dwyer and Peter Holmans and Marchini, {Jonathan L.} and Spencer, {Chris C A} and Bryan Howie and Leung, {Hin Tak} and Hartmann, {Annette M.} and M{\"o}ller, {Hans J{\"u}rgen} and Morris, {Derek W.} and YongYong Shi and GuoYin Feng and Per Hoffmann and Peter Propping and Catalina Vasilescu and Wolfgang Maier and Marcella Rietschel and Stanley Zammit and Johannes Schumacher and Quinn, {Emma M.} and Schulze, {Thomas G.} and Williams, {Nigel M.} and Ina Giegling and Nakao Iwata and Masashi Ikeda and Ariel Darvasi and Sagiv Shifman and Lin He and Jubao Duan and Sanders, {Alan R.} and Levinson, {Douglas F.} and Gejman, {Pablo V.} and Buccola, {Nancy G.} and Mowry, {Bryan J.} and Robert Freedman and Farooq Amin and Black, {Donald W.} and Silverman, {Jeremy M.} and Byerley, {William F.} and Cloninger, {C. Robert} and Sven Cichon and N{\"o}then, {Markus M.} and Michael Gill and Aiden Corvin and Dan Rujescu and George Kirov and Owen, {Michael J.}",

year = "2008",

month = sep,

doi = "10.1038/ng.201",

language = "English (US)",

volume = "40",

pages = "1053--1055",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Publishing Group",

number = "9",

}

TY - JOUR

T1 - Identification of loci associated with schizophrenia by genome-wide association and follow-up

AU - O'Donovan, Michael C.

AU - Craddock, Nicholas

AU - Norton, Nadine

AU - Williams, Hywel

AU - Peirce, Timothy

AU - Moskvina, Valentina

AU - Nikolov, Ivan

AU - Hamshere, Marian

AU - Carroll, Liam

AU - Georgieva, Lyudmila

AU - Dwyer, Sarah

AU - Holmans, Peter

AU - Marchini, Jonathan L.

AU - Spencer, Chris C A

AU - Howie, Bryan

AU - Leung, Hin Tak

AU - Hartmann, Annette M.

AU - Möller, Hans Jürgen

AU - Morris, Derek W.

AU - Shi, YongYong

AU - Feng, GuoYin

AU - Hoffmann, Per

AU - Propping, Peter

AU - Vasilescu, Catalina

AU - Maier, Wolfgang

AU - Rietschel, Marcella

AU - Zammit, Stanley

AU - Schumacher, Johannes

AU - Quinn, Emma M.

AU - Schulze, Thomas G.

AU - Williams, Nigel M.

AU - Giegling, Ina

AU - Iwata, Nakao

AU - Ikeda, Masashi

AU - Darvasi, Ariel

AU - Shifman, Sagiv

AU - He, Lin

AU - Duan, Jubao

AU - Sanders, Alan R.

AU - Levinson, Douglas F.

AU - Gejman, Pablo V.

AU - Buccola, Nancy G.

AU - Mowry, Bryan J.

AU - Freedman, Robert

AU - Amin, Farooq

AU - Black, Donald W.

AU - Silverman, Jeremy M.

AU - Byerley, William F.

AU - Cloninger, C. Robert

AU - Cichon, Sven

AU - Nöthen, Markus M.

AU - Gill, Michael

AU - Corvin, Aiden

AU - Rujescu, Dan

AU - Kirov, George

AU - Owen, Michael J.

PY - 2008/9

Y1 - 2008/9

N2 - We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P <10-5 in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong independent support (P <5 × 10-4), and the overall pattern of replication was unlikely to occur by chance (P = 9 × 10-8). Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 × 10-7) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 × 10-9).

AB - We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P <10-5 in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong independent support (P <5 × 10-4), and the overall pattern of replication was unlikely to occur by chance (P = 9 × 10-8). Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 × 10-7) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 × 10-9).

UR - http://www.scopus.com/inward/record.url?scp=50449100461&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=50449100461&partnerID=8YFLogxK

U2 - 10.1038/ng.201

DO - 10.1038/ng.201

M3 - Article

C2 - 18677311

AN - SCOPUS:50449100461

SN - 1061-4036

VL - 40

SP - 1053

EP - 1055

JO - Nature Genetics

JF - Nature Genetics

IS - 9

ER -

Identification of loci associated with schizophrenia by genome-wide association and follow-up

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this