Identification of human immunodeficiency virus primary isolates resistant to interferon-α and correlation of prevalence to disease progression

Myriam S. Kiinzi, Homayoon Farzadegan, Joseph B. Margolick, David Vlahov, Paula M. Pitha

Research output: Contribution to journalArticlepeer-review

Abstract

Human immunodeficiency virus (HIV) primary isolates, derived from donors at various stages of HIV infection, were assayed for their sensitivity to interferon (IFN)-α2 in vitro. These isolates displayed a broad range of sensitivity to IFN-a2. The prevalence of IFN-α2 resistance was low in the absence of AIDS but dramatically increased once HIV infection progressed to AIDS. Although there was no linear correlation between the percentage of IFN-α2 inhibition in vitro and the CD4 cell number in vivo or the level of endogenous IFN-α, serum IFN-α levels were higher in donors with AIDS and were associated with low CD4 cell numbers. Thus, circulating IFN-α appeared to either promote resistance or favor survival of IFN-a-resistant variants. IFN-α2 resistance was neither limited to a particular cell tropism nor enhanced by therapy with zidovudine. Sequential analysis indicated that reversion to IFN-α2 sensitivity could occur during the course of infection.

Original languageEnglish (US)
Pages (from-to)822-828
Number of pages7
JournalJournal of Infectious Diseases
Volume171
Issue number4
DOIs
StatePublished - Apr 1995

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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