Abstract
Population structure is well known as a prevalent and important factor in genetic studies, but its relevance in epigenetics is unclear. Very little is known about the affected epigenetic markers and their connections with genetics. In this study we assessed the impact of population diversity on genome wide single nucleotide polymorphisms (SNPs) and DNA methylation levels in 196 participants from five ethnic groups, using principle and independent component analyses. Three population stratification factors (PSFs) were identified in the genomic SNP dataset, accounting for a relatively large portion of total variance (6%). In contrast, only one PSF was identified in genomic methylation dataset accounting for 0.2% of total variance. This methylation PSF, however, was significantly correlated with the largest SNP PSF (r = 0.72, p
| Original language | English (US) |
|---|---|
| Article number | e13209 |
| Journal | PLoS One |
| Volume | 5 |
| Issue number | 10 |
| DOIs | |
| State | Published - 2010 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine(all)
Cite this
Identification of genetic and epigenetic marks involved in population structure. / Liu, Jingyu; Hutchison, Kent; Perrone-Bizzozero, Nora; Morgan, Marilee; Sui, Jing; Calhoun, Vince Daniel.
In: PLoS One, Vol. 5, No. 10, e13209, 2010.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Identification of genetic and epigenetic marks involved in population structure
AU - Liu, Jingyu
AU - Hutchison, Kent
AU - Perrone-Bizzozero, Nora
AU - Morgan, Marilee
AU - Sui, Jing
AU - Calhoun, Vince Daniel
PY - 2010
Y1 - 2010
N2 - Population structure is well known as a prevalent and important factor in genetic studies, but its relevance in epigenetics is unclear. Very little is known about the affected epigenetic markers and their connections with genetics. In this study we assessed the impact of population diversity on genome wide single nucleotide polymorphisms (SNPs) and DNA methylation levels in 196 participants from five ethnic groups, using principle and independent component analyses. Three population stratification factors (PSFs) were identified in the genomic SNP dataset, accounting for a relatively large portion of total variance (6%). In contrast, only one PSF was identified in genomic methylation dataset accounting for 0.2% of total variance. This methylation PSF, however, was significantly correlated with the largest SNP PSF (r = 0.72, p
AB - Population structure is well known as a prevalent and important factor in genetic studies, but its relevance in epigenetics is unclear. Very little is known about the affected epigenetic markers and their connections with genetics. In this study we assessed the impact of population diversity on genome wide single nucleotide polymorphisms (SNPs) and DNA methylation levels in 196 participants from five ethnic groups, using principle and independent component analyses. Three population stratification factors (PSFs) were identified in the genomic SNP dataset, accounting for a relatively large portion of total variance (6%). In contrast, only one PSF was identified in genomic methylation dataset accounting for 0.2% of total variance. This methylation PSF, however, was significantly correlated with the largest SNP PSF (r = 0.72, p
UR - http://www.scopus.com/inward/record.url?scp=78049243989&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78049243989&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0013209
DO - 10.1371/journal.pone.0013209
M3 - Article
C2 - 20949057
AN - SCOPUS:78049243989
VL - 5
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 10
M1 - e13209
ER -