Identification of genetic and epigenetic marks involved in population structure

Jingyu Liu, Kent Hutchison, Nora Perrone-Bizzozero, Marilee Morgan, Jing Sui, Vince Daniel Calhoun

Research output: Contribution to journalArticle

Abstract

Population structure is well known as a prevalent and important factor in genetic studies, but its relevance in epigenetics is unclear. Very little is known about the affected epigenetic markers and their connections with genetics. In this study we assessed the impact of population diversity on genome wide single nucleotide polymorphisms (SNPs) and DNA methylation levels in 196 participants from five ethnic groups, using principle and independent component analyses. Three population stratification factors (PSFs) were identified in the genomic SNP dataset, accounting for a relatively large portion of total variance (6%). In contrast, only one PSF was identified in genomic methylation dataset accounting for 0.2% of total variance. This methylation PSF, however, was significantly correlated with the largest SNP PSF (r = 0.72, p

Original languageEnglish (US)
Article numbere13209
JournalPLoS One
Volume5
Issue number10
DOIs
StatePublished - 2010
Externally publishedYes

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Polymorphism
Epigenomics
epigenetics
population structure
Methylation
Nucleotides
single nucleotide polymorphism
Population
Single Nucleotide Polymorphism
methylation
genomics
Genes
DNA methylation
nationalities and ethnic groups
DNA Methylation
Ethnic Groups
Genome
genome

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Identification of genetic and epigenetic marks involved in population structure. / Liu, Jingyu; Hutchison, Kent; Perrone-Bizzozero, Nora; Morgan, Marilee; Sui, Jing; Calhoun, Vince Daniel.

In: PLoS One, Vol. 5, No. 10, e13209, 2010.

Research output: Contribution to journalArticle

Liu, J, Hutchison, K, Perrone-Bizzozero, N, Morgan, M, Sui, J & Calhoun, VD 2010, 'Identification of genetic and epigenetic marks involved in population structure', PLoS One, vol. 5, no. 10, e13209. https://doi.org/10.1371/journal.pone.0013209
Liu, Jingyu ; Hutchison, Kent ; Perrone-Bizzozero, Nora ; Morgan, Marilee ; Sui, Jing ; Calhoun, Vince Daniel. / Identification of genetic and epigenetic marks involved in population structure. In: PLoS One. 2010 ; Vol. 5, No. 10.
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